Disparate regulation of interleukin 8 gene expression from blood monocytes, endothelial cells, and fibroblasts by interleukin 4

Biochem Biophys Res Commun. 1990 Sep 14;171(2):531-6. doi: 10.1016/0006-291x(90)91178-u.

Abstract

The role(s) of novel chemotactic cytokines as mediators in the pathogenesis of many acute and chronic disease states is becoming increasingly apparent. One of these cytokines, interleukin 8, is a product of both immune and non-immune cells. In this manuscript, we describe the suppression of IL-8 gene expression from stimulated monocytes by IL-4, while IL-4 had no suppressive effects on IL-8 gene expression from stimulated fibroblasts and endothelial cells. Our data suggest that IL-4 may function as an endogenous regulator of monocyte cytokine expression, including the chemotactic cytokine IL-8.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chemotactic Factors / biosynthesis
  • Chemotactic Factors / blood
  • Chemotactic Factors / genetics*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / immunology*
  • Fibroblasts / drug effects
  • Fibroblasts / immunology
  • Gene Expression / drug effects
  • Humans
  • In Vitro Techniques
  • Interleukin-1 / pharmacology
  • Interleukin-4 / pharmacology*
  • Interleukin-8
  • Interleukins / biosynthesis
  • Interleukins / blood
  • Interleukins / genetics*
  • Monocytes / drug effects
  • Monocytes / immunology*
  • Recombinant Proteins / pharmacology
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Chemotactic Factors
  • Interleukin-1
  • Interleukin-8
  • Interleukins
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Interleukin-4