Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation

Nat Rev Rheumatol. 2011 Sep 20;7(11):626-8. doi: 10.1038/nrrheum.2011.133.

Abstract

Repair of bone erosions in rheumatoid arthritis has been considered a difficult goal to achieve. However—with better therapies at hand to control synovial inflammation—sensitive μCT imaging techniques now available confirm that repair of bone erosion is possible, and begins at the base of erosive lesions.

Publication types

  • News
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology
  • Bone Resorption / drug therapy*
  • Bone Resorption / physiopathology
  • Drug Therapy, Combination
  • Humans
  • Methotrexate / therapeutic use*
  • Osteogenesis / physiology
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Tumor Necrosis Factor-alpha
  • Methotrexate