Serum resistin level is associated with radiographic changes in hand osteoarthritis: cross-sectional study

Objective: The aim of this study was to determine whether adipokines such as adiponectin and resistin were related to radiographic outcomes in patients with hand osteoarthritis (OA).

Methods: A total of 156 female subjects (46 controls, 60 non-radiographic hand OA, and 50 radiographic hand OA) were enrolled. We measured serum adiponectin and resistin concentrations using an enzyme-linked immunosorbent assay (ELISA). Radiographic hand OA was defined by the presence of a ≥2 Kellgren-Lawrence radiological grade after assessment for 20 joints of both hands. The association between radiographic hand OA and each adipokine was assessed using multivariate logistic regression models controlling for confounding clinical parameters.

Results: Serum resistin levels in radiographic hand OA patients were higher than in non-radiographic hand OA and controls (p(adj)=0.020 and p(adj)=0.019, respectively), whereas there were no significant differences in serum adiponectin levels. The presence of radiographic changes in hand OA was shown to be dependent on serum resistin levels (p(adj)=0.028). Specifically, subchondral erosion in radiographic hand OA was associated with serum resisitin (p(adj)=0.028). However, there were no associations of serum adipokines with joint space narrowing, bony ankylosis, and cortical destruction.

Conclusions: This study suggests that resistin is involved in radiographic changes in hand OA, and that adipokines contribute to pathogenesis in radiographic outcomes in hand OA.