Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with review of the relevant published work

J Dermatol. 2011 Feb;38(2):155-9. doi: 10.1111/j.1346-8138.2010.00931.x. Epub 2010 Nov 11.

Abstract

Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is characterized by various dermatological manifestations and osteoarthropathy frequently localized to the anterior chest wall. Dermatologists should be familiar with this syndrome. Its early diagnosis is important to avoid prolonged antibiotic treatments and unnecessary invasive procedures. We report a new case of this syndrome with review of the relevant published work.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acquired Hyperostosis Syndrome / drug therapy
  • Acquired Hyperostosis Syndrome / pathology*
  • Adult
  • Dermatologic Agents / therapeutic use
  • Diagnosis, Differential
  • Female
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / pathology*
  • Humans
  • Isoxazoles / therapeutic use
  • Leflunomide
  • Leg Dermatoses / drug therapy
  • Leg Dermatoses / pathology*
  • Methotrexate / therapeutic use
  • Treatment Outcome

Substances

  • Dermatologic Agents
  • Isoxazoles
  • Leflunomide
  • Methotrexate