The role of Th17 lymphocytes in the autoimmune and chronic inflammatory diseases

Intern Emerg Med. 2011 Dec;6(6):487-95. doi: 10.1007/s11739-011-0517-7. Epub 2011 Jan 22.

Abstract

The emerging role of interleukin-17 as a hallmark proinflammatory cytokine of the adaptive immune system produced by a new T helper cell subset termed "Th17" has received considerable attention. In this review we will focus on recent information regarding IL-17 and its relevance in autoimmune and chronic inflammatory diseases.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / metabolism
  • Asthma / metabolism
  • Autoimmunity*
  • Chronic Disease*
  • Crohn Disease / metabolism
  • Humans
  • Interleukin-17 / immunology*
  • Lupus Erythematosus, Systemic / metabolism
  • Multiple Sclerosis / metabolism
  • Psoriasis / metabolism
  • Rhinitis, Allergic, Seasonal / metabolism
  • T-Lymphocytes, Helper-Inducer / immunology*

Substances

  • Interleukin-17