Anti-melanoma differentiation-associated gene 5 antibody is a diagnostic and predictive marker for interstitial lung diseases associated with juvenile dermatomyositis

Ichiro Kobayashi; Yuka Okura; Masafumi Yamada; Nobuaki Kawamura; Masataka Kuwana; Tadashi Ariga

doi:10.1016/j.jpeds.2010.11.033

Anti-melanoma differentiation-associated gene 5 antibody is a diagnostic and predictive marker for interstitial lung diseases associated with juvenile dermatomyositis

J Pediatr. 2011 Apr;158(4):675-7. doi: 10.1016/j.jpeds.2010.11.033. Epub 2011 Jan 13.

Authors

Ichiro Kobayashi¹, Yuka Okura, Masafumi Yamada, Nobuaki Kawamura, Masataka Kuwana, Tadashi Ariga

Affiliation

¹ Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ichikobaya@med.hokudai.ac.jp

PMID: 21232756
DOI: 10.1016/j.jpeds.2010.11.033

Abstract

The presence of the anti-melanoma differentiation-associated gene 5 antibody was evaluated in 13 patients with juvenile dermatomyositis (JDM). The antibody was positive in 5 of the 6 patients with JDM-associated interstitial lung disease (ILD), but not in the 7 patients without ILD. This antibody is a useful marker for early diagnosis of JDM-associated ILD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Anti-Idiotypic / immunology
Autoantibodies / immunology
Child
Child, Preschool
DEAD-box RNA Helicases / immunology*
Dermatomyositis / complications
Dermatomyositis / immunology
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interferon-Induced Helicase, IFIH1
Lung Diseases, Interstitial / diagnosis*
Lung Diseases, Interstitial / etiology*
Lung Diseases, Interstitial / immunology
Male
Retrospective Studies

Substances

Antibodies, Anti-Idiotypic
Autoantibodies
IFIH1 protein, human
DEAD-box RNA Helicases
Interferon-Induced Helicase, IFIH1

Supplementary concepts

Amyopathic dermatomyositis