Abstract
The occurrence of MHC antigens on epithelial cells in lip salivary glands obtained from patients with various connective tissue diseases and from bone marrow recipients was studied. The amount of infiltrating lymphocytes correlated to an increase in MHC class I and II antigen expression, but not to diagnosis or glandular function. Interferon-gamma + infiltrating cells were scanty. The role of interferon-gamma as the main inducer of MHC antigens and the notion "aberrant" HLA-DR thought to perpetuate chronic autoimmune disease are questioned.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Biopsy
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Bone Marrow Transplantation / immunology
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Bone Marrow Transplantation / pathology
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Cell Movement / physiology
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Connective Tissue Diseases / immunology
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Connective Tissue Diseases / pathology
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Epithelial Cells
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Epithelium / immunology
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Epithelium / metabolism
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Epithelium / pathology
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Female
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Histocompatibility Antigens Class I / immunology
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Histocompatibility Antigens Class I / metabolism*
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Antigens Class II / metabolism*
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Humans
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Immunohistochemistry
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Interferon-gamma / metabolism*
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Interferon-gamma / physiology
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Lymphocytes / cytology
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Lymphocytes / immunology
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Lymphocytes / metabolism*
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Male
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Middle Aged
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Salivary Glands / cytology
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Salivary Glands / immunology
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Salivary Glands / metabolism
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Salivary Glands / pathology
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Sjogren's Syndrome / immunology
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Sjogren's Syndrome / metabolism
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Sjogren's Syndrome / pathology
Substances
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Histocompatibility Antigens Class I
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Histocompatibility Antigens Class II
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Interferon-gamma