Adaptive clinical trial design: has its time come?

MeSH terms

• Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
• Biomarkers, Tumor / genetics
• Biomarkers, Tumor / metabolism*
• Breast Neoplasms / drug therapy
• Carcinoma, Non-Small-Cell Lung / drug therapy
• Clinical Trials as Topic / standards*
• Cyclin D1 / metabolism
• ErbB Receptors / metabolism
• Female
• Humans
• Lung Neoplasms / drug therapy
• Mutation
• Neoplasms / metabolism
• Neoplasms / therapy*
• Proto-Oncogene Proteins / metabolism
• Proto-Oncogene Proteins B-raf / metabolism
• Proto-Oncogene Proteins p21(ras)
• Research Design / standards*
• Retinoid X Receptors / metabolism
• Vascular Endothelial Growth Factor A / metabolism
• ras Proteins / metabolism