Transient iatrogenic immunodeficiency-related B-cell lymphoproliferative disorder of the skin in a patient with mycosis fungoides/Sézary syndrome

Jonathan L Curry; Victor G Prieto; Dan M Jones; Franscisco Vega; Madeleine Duvic; A Hafeez Diwan

doi:10.1111/j.1600-0560.2009.01459.x

Transient iatrogenic immunodeficiency-related B-cell lymphoproliferative disorder of the skin in a patient with mycosis fungoides/Sézary syndrome

J Cutan Pathol. 2011 Mar;38(3):295-7. doi: 10.1111/j.1600-0560.2009.01459.x.

Authors

Jonathan L Curry¹, Victor G Prieto, Dan M Jones, Franscisco Vega, Madeleine Duvic, A Hafeez Diwan

Affiliation

¹ Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. jlcurry@mdanderson.org

PMID: 19889052
DOI: 10.1111/j.1600-0560.2009.01459.x

Abstract

Immunodeficiency-related lymphoproliferative disorders (IR-LPD) may occur in the setting of immunosuppressive therapy with methotrexate and TNF-α antagonists. As far as we are aware, this is the first report of an Epstein-Barr virus-associated B-cell lymphoproliferative disorder, secondary to methotrexate therapy in a patient with mycosis fungoides/Sézary syndrome.

Publication types

Case Reports

MeSH terms

Aged
Azathioprine / therapeutic use
B-Lymphocytes / pathology
Epstein-Barr Virus Infections / complications
Humans
Immunocompromised Host*
Immunosuppressive Agents / therapeutic use
Lymphoproliferative Disorders / complications
Lymphoproliferative Disorders / immunology*
Lymphoproliferative Disorders / virology
Male
Methotrexate / therapeutic use
Mycosis Fungoides / complications*
Mycosis Fungoides / drug therapy
Prednisone / therapeutic use
Sezary Syndrome / complications*
Sezary Syndrome / drug therapy
Skin Neoplasms / complications*
Skin Neoplasms / drug therapy

Substances

Immunosuppressive Agents
Azathioprine
Prednisone
Methotrexate