Illuminating the black box of TNF action in tuberculous granulomas

Immunity. 2008 Aug 15;29(2):175-7. doi: 10.1016/j.immuni.2008.07.003.

Abstract

TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Embryo, Nonmammalian
  • Granuloma / immunology*
  • Granuloma / metabolism
  • Homeodomain Proteins / immunology
  • Homeodomain Proteins / metabolism*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mycobacterium Infections, Nontuberculous / immunology*
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Mycobacterium marinum / immunology
  • Tuberculosis / immunology*
  • Tuberculosis / metabolism
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / metabolism*
  • Zebrafish / embryology
  • Zebrafish / immunology
  • Zebrafish / metabolism
  • Zebrafish / microbiology

Substances

  • Homeodomain Proteins
  • Tumor Necrosis Factor-alpha