The role of bone in osteoarthritis pathogenesis

Rheum Dis Clin North Am. 2008 Aug;34(3):561-71. doi: 10.1016/j.rdc.2008.07.001.

Abstract

This article focuses on the specific skeletal features of osteoarthritis and the putative mechanisms involved in their pathogenesis. In addition, the relationship of these changes to the alterations in articular cartilage and the other tissues comprising the diarthrodial joint are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Density
  • Bone Remodeling / physiology
  • Bone Resorption
  • Bone and Bones / pathology*
  • Bone and Bones / physiopathology
  • Cartilage, Articular / pathology*
  • Cartilage, Articular / physiopathology
  • Disease Progression
  • Female
  • Humans
  • Male
  • Osteoarthritis / pathology*
  • Osteoarthritis / physiopathology
  • Osteoarthritis, Hip / pathology
  • Osteoarthritis, Hip / physiopathology
  • Osteoarthritis, Knee / pathology
  • Osteoarthritis, Knee / physiopathology
  • Prognosis
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Synovial Membrane / pathology*
  • Synovial Membrane / physiopathology