Abstract
Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Depressive Disorder, Major / physiopathology*
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Humans
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Hypothalamo-Hypophyseal System / physiopathology*
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Pituitary-Adrenal System / physiopathology*
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Receptors, Glucocorticoid / physiology*
Substances
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Receptors, Glucocorticoid