Abstract
Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system. We present a case of sacroiliitis (a relatively uncommon feature) and sensorimotor demyelinating polyneuropathy, which has been reported previously in only a few cases during isotretinoin therapy. Clinical symptoms were improved after the withdrawal of isotretinoin and the follow-up electrophysiological study performed 2 years after the initial diagnosis of polyneuropathy showed mild improvement. Dermatologists are advised to be alert to symptoms of polyneuropathy and sacroiliitis during treatment with isotretinoin.
MeSH terms
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Acne Vulgaris / drug therapy
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Adult
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Arthritis / chemically induced*
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Arthritis / metabolism
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Demyelinating Diseases / chemically induced*
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Demyelinating Diseases / diagnostic imaging
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Dermatologic Agents / administration & dosage
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Dermatologic Agents / adverse effects*
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Dose-Response Relationship, Drug
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Humans
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Isotretinoin / administration & dosage
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Isotretinoin / adverse effects*
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Male
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Polyneuropathies / chemically induced*
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Polyneuropathies / diagnostic imaging
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Radiography
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Sacroiliac Joint / diagnostic imaging
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Sacroiliac Joint / drug effects*
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Sacroiliac Joint / metabolism
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Treatment Outcome
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Withholding Treatment
Substances
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Dermatologic Agents
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Isotretinoin