A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

S E L Temple; C M Almeida; K Y Cheong; R G Wunderink; G W Waterer

doi:10.1111/j.1744-313X.2007.00674.x

A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

Int J Immunogenet. 2007 Jun;34(3):157-60. doi: 10.1111/j.1744-313X.2007.00674.x.

Authors

S E L Temple¹, C M Almeida, K Y Cheong, R G Wunderink, G W Waterer

Affiliation

¹ School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia. setemple@cyllene.uwa.edu.au

PMID: 17504504
DOI: 10.1111/j.1744-313X.2007.00674.x

Abstract

We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

MeSH terms

Adult
Escherichia coli*
Female
Genotype
Humans
Leukocytes, Mononuclear / drug effects
Leukocytes, Mononuclear / metabolism
Lipopolysaccharides / pharmacology
Lymphotoxin-alpha / genetics*
Male
Polymorphism, Genetic*
Promoter Regions, Genetic
RNA, Messenger / metabolism
Streptococcus pneumoniae*

Substances

Lipopolysaccharides
Lymphotoxin-alpha
RNA, Messenger