Abstract
The secondary role of pathology in the present clinical management of pulmonary hypertension (PH) reflects to some extent the limitations of the current understanding of the disease. Ample room exists for the diagnostic translation of the pathobiologic studies, with the goal of improving the diagnostic and prognostic power of the pathologic assessment of pulmonary vascular remodeling. This article seeks to show the complementarities of the pathology and pathobiology of PH.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Apoptosis / physiology
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Bone Morphogenetic Protein Receptors, Type II / physiology
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Bone Morphogenetic Proteins / physiology
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Collagen / analysis
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Endothelial Cells / pathology
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Endothelial Cells / physiology
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Endothelium / pathology
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Fibroblasts / physiology
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Gene Products, nef / physiology
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Humans
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Hypertension, Pulmonary / pathology*
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Hypertension, Pulmonary / physiopathology
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Hypertrophy
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Immunohistochemistry
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Inflammation Mediators / physiology
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Pulmonary Artery / pathology
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Vascular Resistance / physiology
Substances
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Bone Morphogenetic Proteins
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Gene Products, nef
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Inflammation Mediators
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Collagen
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BMPR2 protein, human
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Bone Morphogenetic Protein Receptors, Type II