Drug eruption due to bosentan in a patient with systemic sclerosis

Yayoi Nagai; Masayoshi Yamanaka; Shigeru Nishimura; Akihiko Nakano; Akira Hasegawa; Osamu Ishikawa

doi:10.1007/s10165-006-0477-3

Drug eruption due to bosentan in a patient with systemic sclerosis

Mod Rheumatol. 2006;16(3):188-90. doi: 10.1007/s10165-006-0477-3.

Authors

Yayoi Nagai¹, Masayoshi Yamanaka, Shigeru Nishimura, Akihiko Nakano, Akira Hasegawa, Osamu Ishikawa

Affiliation

¹ Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, 371-8511, Japan. yanagai@showa.gunma-u.ac.jp

PMID: 16767560
DOI: 10.1007/s10165-006-0477-3

Abstract

We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Since the use of bosentan is expected to increase, we should be aware of the previously unknown adverse effects as well as skin eruptions.

Publication types

Case Reports

MeSH terms

Anti-Inflammatory Agents / administration & dosage*
Antihypertensive Agents / adverse effects*
Bosentan
Drug Eruptions*
Endothelin Receptor Antagonists*
Eosinophilia / etiology
Female
Humans
Hypertension, Pulmonary / complications
Hypertension, Pulmonary / drug therapy*
Middle Aged
Prednisolone / administration & dosage
Scleroderma, Systemic / complications
Sulfonamides / adverse effects*

Substances

Anti-Inflammatory Agents
Antihypertensive Agents
Endothelin Receptor Antagonists
Sulfonamides
Prednisolone
Bosentan