Abstract
The pathogenesis of SLE is multifactorial. Immune complexes, autoantibodies, and abnormal T-lymphocyte responses all play a part. Genetic predispositions are present, but not as strongly expressed as in the spondylarthropathies. Environmental agents and the effects of sex hormones also contribute.
MeSH terms
-
Adolescent
-
Animals
-
Arachidonic Acid / metabolism
-
Autoantibodies / analysis
-
Biomarkers / analysis
-
Complement Activation
-
Cytokines / metabolism
-
Disease Models, Animal
-
Female
-
Humans
-
Lupus Erythematosus, Systemic / diagnosis
-
Lupus Erythematosus, Systemic / etiology*
-
Lupus Erythematosus, Systemic / immunology
-
Male
-
Mice
-
Rheumatic Diseases / etiology*
-
Rheumatic Diseases / genetics
-
Rheumatic Diseases / immunology
-
Sex Factors
Substances
-
Autoantibodies
-
Biomarkers
-
Cytokines
-
Arachidonic Acid