Organizing Pneumonia with a Positive Result for Anti-CCP Antibodies as the First Clinical Presentation of Rheumatoid Arthritis

Kosaku Komiya; Shinji Teramoto; Yuichiro Kurosaki; Fumihiro Kashizaki; Masahiro Kawashima; Kimihiko Masuda; Shinobu Akagawa; Akira Hebisawa; Hiroshi Ishii; Jun-ichi Kadota

doi:10.2169/internalmedicine.49.3609

CASE REPORTS

Organizing Pneumonia with a Positive Result for Anti-CCP Antibodies as the First Clinical Presentation of Rheumatoid Arthritis

Kosaku Komiya, Shinji Teramoto, Yuichiro Kurosaki, Fumihiro Kashizaki, Masahiro Kawashima, Kimihiko Masuda, Shinobu Akagawa, Akira Hebisawa, Hiroshi Ishii, Jun-ichi Kadota

Author information

Kosaku Komiya
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Department of Respiratory Medicine, Oita University Hospital
Shinji Teramoto
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Yuichiro Kurosaki
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Fumihiro Kashizaki
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Masahiro Kawashima
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Kimihiko Masuda
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Shinobu Akagawa
Department of Respiratory Medicine, National Hospital Organization, Tokyo National Hospital
Akira Hebisawa
Department of Pathology, National Hospital Organization, Tokyo National Hospital
Hiroshi Ishii
Department of Respiratory Medicine, Oita University Hospital
Jun-ichi Kadota
Department of Respiratory Medicine, Oita University Hospital

Keywords: anti-CCP antibodies, interstitial lung disease, organizing pneumonia, rheumatoid arthritis

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 15 Pages 1605-1607

DOI https://doi.org/10.2169/internalmedicine.49.3609

Details

Abstract

We report an 86-year-old woman who presented with organizing pneumonia (OP) with a positive anti-cyclic citrullinated peptide (anti-CCP) antibodies as the first manifestation of rheumatoid arthritis (RA). She experienced dyspnea, chest X-ray showed diffuse alveolar exudates indicated OP histologically. Although she did not present with articular symptoms initially, anti-CCP antibodies measured for differentiation of RA were positive. Eight months later, she showed representative manifestations of RA. Even though OP following joint involvement is frequent in RA, in rare cases it could be the first manifestation. This is the first case showing OP with a positive result for anti-CCP antibodies as the first manifestation of RA.

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