Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier

Hiroshi Fujiwara; Daisuke Nakamura; Toshimasa Kukita; Heiichiro Hamada; Atsuo Ozaki; Kakushi Matsushita; Tadashi Matsumoto; Chuwa Tei

doi:10.2169/internalmedicine.45.1490

CASE REPORTS

Immunosuppressive Treatment for Mixed Connective Tissue Disease May Facilitate the Development of Adult T Cell Leukemia/Lymphoma in a HTLVI Carrier

Hiroshi Fujiwara, Daisuke Nakamura, Toshimasa Kukita, Heiichiro Hamada, Atsuo Ozaki, Kakushi Matsushita, Tadashi Matsumoto, Chuwa Tei

Author information

Hiroshi Fujiwara
Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima
Daisuke Nakamura
Division of Hematology and Oncology, Jiaikai Imamura Hospital, Kagoshima
Toshimasa Kukita
Division of Hematology and Oncology, Jiaikai Imamura Hospital, Kagoshima
Heiichiro Hamada
Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima
Atsuo Ozaki
Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima
Kakushi Matsushita
Division of Hematology and Immunology, Department of Internal Medicine, Kagoshima University, Kagoshima
Tadashi Matsumoto
Division of Hematology and Oncology, Jiaikai Imamura Hospital, Kagoshima
Chuwa Tei
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School, Kagoshima University, Kagoshima

Keywords: adult Tcell leukemia/lymphoma (ATLL), mixed connective tissue disease (MCTD), cytotoxic Tcell (CTL), human Tlymphotropic virus type I (HTLVI)

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 5 Pages 297-301

DOI https://doi.org/10.2169/internalmedicine.45.1490

Details

Abstract

A 66yearold woman who was positive for human Tlymphotropic virus type I (HTLVI) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTLVIrelated inflammatory diseases, however the development of ATLL during the treatment of HTLVIrelated MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTDcausative antiHTLVI immune response and antiATLL immune response.

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