Chest
Clinical Investigations: Xercise/ClerodermaCardiorespiratory Responses to Incremental Exercise in Patients With Systemic Sclerosis
Section snippets
Study Population
Seventy-eight consecutive patients were referred to our department from the Department of Dermatology in the years 1993 and 1994 to evaluate lung involvement. All patients fulfilled the American Rheumatism Association criteria for the classification of systemic sclerosis, with or without clinical evidence of pulmonary involvement.15 There were 53 women and 25 men; the mean age was 51 years (range, 20 to 79 years) (Table 1). Twenty-one percent of the patients showed the characteristic
Pulmonary Function Tests
Pulmonary function test results and arterial blood gas values are shown in Table 2. The study group did not show a significant reduction in lung volumes or an increased bronchial obstruction. The Dco had a wide range from 38 to 132% of predicted.
When patients with ISSc and with dSSc were compared, significant differences in FVC, RV, TLC, and Dco could be demonstrated (Table 1). MEF50 and FEV1/FVC were not significantly different in the two groups. Significant differences measured in arterial
Discussion
The present study was designed to evaluate the usefulness of cardiopulmonary exercise testing in estimating disease severity and to detect possible transition from the limited to the diffuse form of systemic sclerosis. Comparing limited with diffuse systemic sclerosis, those patients with lung involvement were characterized by a significantly lower Dco, whereas an evident airways obstruction was not present in the two groups. In contrast to the study by Pistelli,20 we did not find patients
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Cited by (37)
Cardiopulmonary exercise testing in the management of systemic sclerosis
2022, Revue de Medecine InterneExercise Pathophysiology in Interstitial Lung Disease
2019, Clinics in Chest MedicineCitation Excerpt :However, patients with ILD commonly have low heart rates at peak exercise due to cessation of exercise before a physiologic maximum is reached.74 Yet, patients with ILD with significant degrees of cardiovascular involvement, such as scleroderma75 or sarcoidosis,73 often have a low cardiac reserve at peak exercise, indicating that exercise limitation is likely the result of cardiovascular factors in these patients.74 Exercise usually worsens the central hemodynamic abnormalities observed at rest in patients with ILD: for instance, the right ventricular afterload increases out of proportion to cardiac output, leading to higher pulmonary arterial pressures.
Clinical Exercise Testing
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionRelationship between functional capacity, joint mobility and pulmonary function in patients with systemic sclerosis
2015, Journal of Bodywork and Movement TherapiesCitation Excerpt :Because it is a multisystemic disease, several factors can potentially limit exercise in patients with SS. Previous studies have described abnormalities in gas exchange at rest and during exercise in patients with SS (Schwaiblmair et al., 1996). More recently, Dumitrescu et al. (2010), using the cardiopulmonary exercise test, observed that pulmonary vasculopathy and left ventricular dysfunction limit exercise capacity in these patients from an early stage.
Dyspnea on exertion in scleroderma: from symptom to diagnosis
2009, Presse MedicaleResponses to exercise in systemic sclerosis-associated interstitial lung disease
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