Chest
Clinical Investigations; Articles; Interstitial Lung DiseaseKL-6: A Serum Marker for Interstitial Pneumonia
Section snippets
Subjects
The subjects of this study consisted of 112 patients admitted to the Department of Pulmonary Medicine between 1987 and 1994. There were 12 patients with bacterial pneumonia, 7 with aspergillus infection, 10 with bronchial asthma, 14 with pulmonary emphysema, 14 with bronchiectasis, 10 with pulmonary tuberculosis, 10 with hypersensitivity pneumonitis (HP), 16 with pneumonitis related to collagen diseases, and 19 with idiopathic interstitial pneumonia (IIP). Additional blood samples were also
Results
A total of 118 samples from 112 patients were measured, including 51 samples with three classes of interstitial lung disease and 67 samples with 6 classes of noninterstitial lung diseases. A summary of the data are shown in Figure 1. The KL-6 value was elevated in the patients with interstitial lung diseases (1,187±689 U/mL; range, 224 to 2,656 U/mL), compared with those without pneumonitis (309±157 U/mL; range, 123 to 855 U/mL). The mean value in the patients with IP was significantly higher
Discussion
The management of IP is difficult, because its prognosis is usually poor and useful markers of disease activity have not been established.1,3 Chest radiography, lung function testing, blood gas analysis, and determination of the serum C-reactive protein and LDH are usually used during management of this disease, the information provided is generally nonspecific, and it is of Ten influenced by bacterial infection or inflammatory processes affecting other organs.2 In addition, these variables are
References (14)
- et al.
Monitoring of serum KL-6 antigen in a patient with radiation pneumonia
Chest
(1992) - et al.
Circulating antigen KL-6 and lactate dehydrogenase for monitoring irradiated patients with lung cancer
Chest
(1992) - et al.
Cryptogenic fibrosing alveolitis: clinical features and their influence on survival
Thorax
(1980) Serum lactic dehydrogenase activity and diffuse interstitial pneumonitis
JAMA
(1968)- et al.
Interstitial lung diseases of unknown cause: disorders characterized by chronic inflammation of the lower respiratory tract
N Engl J Med
(1984) - et al.
Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma
Jpn J Clin Oncol
(1985) - et al.
A novel method for screening monoclonal antibodies reacting with antigenic determinants on soluble antigens: a reversed indirect enzyme-linked immunosorbent assay (RI-ELISA)
Hiroshima J Med Sci
(1987)
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