Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis

Yoshiko Ikawa; Masahiko Suzuki; Satoshi Shiono; Emi Ohki; Hideshige Moriya; Etsuko Negishi; Koichi Ueno

doi:10.1248/bpb.28.2016

Notes

Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis

Yoshiko Ikawa, Masahiko Suzuki, Satoshi Shiono, Emi Ohki, Hideshige Moriya, Etsuko Negishi, Koichi Ueno

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Keywords: histamine H4 receptor (H4R) expression, synovial cell, rheumatoid arthritis

JOURNAL FREE ACCESS

2005 Volume 28 Issue 10 Pages 2016-2018

DOI https://doi.org/10.1248/bpb.28.2016

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Abstract

While histamine H4 receptor (H4R) has been implicated in immune system disturbances in different organ tissues, the presence and possible roles of H4R in synovial cells (SC) of rheumatoid arthritis (RA) patients has not previously been documented. This study conclusively evidences H4R expression in SC of RA patients by use of RT-PCR method. As RA consists mainly of immunological disturbances in SC of RA patients, this study's findings document a novel histamine action site, and opens potential new avenues to investigate mechanisms and to develop pharmacotherapeutic agents for the disease.

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