Article
APOL1 Kidney Risk Alleles: Population Genetics and Disease Associations

https://doi.org/10.1053/j.ackd.2014.06.005Get rights and content

APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2 variants (termed G1 and G2) with high population frequency have been repeatedly associated with nondiabetic CKDs, with very strong effect size (odds ratios 3-29) in populations of sub-Saharan African descent. This review provides an update on the spectrum of APOL1 kidney disease and on the worldwide distribution of these kidney risk variants. We also summarize the proper way to run a recessive analysis on joint and independent effects of APOL1 G1 and G2 kidney risk variants.

Key Words

Glomerular disease
Apolipoprotein L1
African admixture
APOL1 demographics
Chronic kidney disease

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Financial Disclosure: See Acknowledgments on page 432.

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