Regular ArticleCorticosteroid osteoporosis
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2008, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :Though the underlying disease itself may be associated with an increased incidence of fractures, the chronic use of GCs further enhances this increased risk by a factor of 2 (Da Silva et al., 2006). There is strong support for the concept that patients under GC tend to suffer fractures at a higher bone mineral density than controls, suggesting that these medications deteriorate bone resistance beyond densitometry-based expectations (Sambrook and Lane, 2001). GC-induced osteoporosis seems, on the other hand, reversible after stopping the medication and several drugs and other interventions have been shown to prevent GC-induced osteoporosis and associated fractures.
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