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Use of MRI as an outcome measure in clinical trials in RA

Following a decade of substantial improvements in sensitivity and usability, MRI is increasingly used to assess primary outcomes of therapeutic trials in rheumatoid arthritis (RA). In the wake of an MRI-based evaluation of treatment efficacy, what lessons are emerging about the clinical value of this technique for patients with RA?

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References

  1. Conaghan, P. G. et al. Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2012-201611.

  2. Haavardsholm, E. A. et al. Monitoring anti-TNFα treatment in rheumatoid arthritis: responsiveness of magnetic resonance imaging and ultrasonography of the dominant wrist joint compared with conventional measures of disease activity and structural damage. Ann. Rheum. Dis. 68, 1572–1579 (2009).

    Article  CAS  Google Scholar 

  3. Gandjbakhch, F. et al. Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity state. J. Rheumatol. 38, 2039–2044 (2011).

    Article  Google Scholar 

  4. Hetland, M. L. et al. MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA). Ann. Rheum. Dis. 68, 384–390 (2009).

    Article  CAS  Google Scholar 

  5. Døhn, U. M. et al. No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study. Ann. Rheum. Dis. 70, 252–258 (2011).

    Article  Google Scholar 

  6. Bruynesteyn, K., Boers, M., Kostense P, van der Linden S, van der Heijde, D. Deciding on progression of joint damage in paired films of individual patients: smallest detectable difference or change. Ann. Rheum. Dis. 64, 179–182 (2005).

    Article  CAS  Google Scholar 

  7. Østergaard, M. et al. Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patients. Arthritis Rheum. 63, 3712–3722 (2011).

    Article  Google Scholar 

  8. Conaghan, P. G. et al. Assessment by MRI of inflammation and damage in rheumatoid arthritis patients with methotrexate inadequate response receiving golimumab: results of the GO-FORWARD trial. Ann. Rheum. Dis. 70, 1968–1974 (2011).

    Article  CAS  Google Scholar 

  9. van den Broek, M. et al. Rapid radiological progression in the first year of early rheumatoid arthritis is predictive of disability and joint damage progression during 8 years of follow-up. Ann. Rheum. Dis. 71, 1530–1533 (2012).

    Article  CAS  Google Scholar 

  10. Emery, P. et al. Exploratory analyses of the association of MRI with clinical, laboratory and radiographic findings in patients with rheumatoid arthritis. Ann. Rheum. Dis. 70, 2126–2130 (2011).

    Article  Google Scholar 

Download references

Acknowledgements

The author wishes to acknowledge financial support from the Netherlands Organisation for Scientific Research, through a Vidi-grant.

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van der Helm–van Mil, A. Use of MRI as an outcome measure in clinical trials in RA. Nat Rev Rheumatol 8, 643–644 (2012). https://doi.org/10.1038/nrrheum.2012.182

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