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Surgery Insight: orthopedic treatment options in rheumatoid arthritis

Abstract

Longstanding rheumatoid arthritis (RA) leads to disability, caused mainly by joint destruction. The current goals of surgical intervention are to restore function and quality of life, prevent joint deterioration, relieve pain, and correct deformity. A number of different surgical treatment options are available to patients with RA, including synovectomy, arthrodesis, joint replacement, and soft tissue and special hand surgery; nonoperative management is also important. Decision-making and timing for orthopedic intervention are complex issues because of polyarticular involvement. Functional impairment, pain, and the subsequent loss of quality of life and inability to work have become the main considerations for surgical reconstruction. Early referral for orthopedic treatment can lead to improved functional benefit for patients with RA. The decision for orthopedic intervention should be established by an interdisciplinary team that includes rheumatologists and orthopedic surgeons experienced in the surgery of RA. Priority should be given to the joint that causes the greatest disability and pain. Disease progression and pharmaceutical treatment options should be taken into consideration when establishing an orthopedic intervention protocol.

Key Points

  • Functional impairment, pain, and the subsequent loss of quality of life and inability to work are main considerations for surgical reconstruction in patients with rheumatoid arthritis

  • Early referral for orthopedic treatment can result in greater functional benefit

  • The decision for orthopedic intervention should be established by an interdisciplinary team that includes rheumatologists and orthopedic surgeons who are experienced in the surgery of patients with rheumatoid arthritis

  • Priority for surgery should be given to the joint that causes the greatest disability and pain

  • Disease progression and pharmaceutical treatment options should be taken into consideration when establishing an orthopedic intervention protocol

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Figure 1: Overview of the main surgical treatment options available to patients with rheumatoid arthritis.
Figure 2: Examples of prosthetic treatment options available for patients with rheumatoid arthritis in the shoulder.

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References

  1. Welsing PM et al. (2005) Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis. Arthritis Rheum 52: 2616–2624

    Article  Google Scholar 

  2. Weiss RJ et al. (2006) Orthopaedic surgery of the lower limbs in 49,802 rheumatoid arthritis patients: results from the Swedish National Inpatient Registry during 1987 to 2001. Ann Rheum Dis 65: 335–341

    Article  CAS  Google Scholar 

  3. Verstappen SM et al. (2004) Overview of work disability in rheumatoid arthritis patients as observed in cross-sectional and longitudinal surveys. Arthritis Rheum 51: 488–497

    Article  CAS  Google Scholar 

  4. Tarner IH et al. (2007) Emerging targets of biologic therapies for rheumatoid arthritis. Nat Clin Pract Rheumatol 3: 336–345

    Article  CAS  Google Scholar 

  5. Müller-Ladner U et al. (2005) Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 1: 102–110

    Article  Google Scholar 

  6. Molenaar ET et al. (2004) Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission. Arthritis Rheum 50: 36–42

    Article  Google Scholar 

  7. Cohen G et al. (2007) Radiological damage in patients with rheumatoid arthritis on sustained remission. Ann Rheum Dis 66: 358–363

    Article  CAS  Google Scholar 

  8. Verstappen SM et al. (2006) Joint surgery in the Utrecht Rheumatoid Arthritis Cohort: the effect of treatment strategy. Ann Rheum Dis 65: 1506–1511

    Article  CAS  Google Scholar 

  9. Scott DL et al. (2000) The links between joint damage and disability in rheumatoid arthritis. Rheumatology (Oxford) 39: 122–132

    Article  CAS  Google Scholar 

  10. van Lankveld WG et al. (1998) Predictors of changes in observed dexterity during one year in patients with rheumatoid arthritis. Br J Rheumatol 37: 733–739

    Article  CAS  Google Scholar 

  11. Katz JN et al. (2007) Association of hospital and surgeon procedure volume with patient–centered outcomes of total knee replacement in a population–based cohort of patients age 65 years and older. Arthritis Rheum 56: 568–574

    Article  Google Scholar 

  12. Hammond JW et al. (2003) Surgeon experience and clinical and economic outcomes for shoulder arthroplasty. J Bone Joint Surg Am 85: 2318–2324

    Article  Google Scholar 

  13. Halm EA et al. (2002) Is volume related to outcome in health care? A systematic review and methodologic critique of the literature. Ann Intern Med 137: 511–520

    Article  Google Scholar 

  14. SBU (Eds; 2000) Rheumatic diseases—surgical treatment: a systematic literature review by SBU—the Swedish Council on Technology Assessment in Health Care. In. Acta Orthop Scand 71 (Suppl 294): 1–88

  15. Bogoch ER and Judd MG (2002) The hand: a second face? J Rheumatol 29: 2477–2483

    PubMed  Google Scholar 

  16. Gariepy R et al. (1966) The prophylactic effect of synovectomy of the knee in rheumatoid arthritis. Can Med Assoc J 94: 1349–1352

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Kerschbaumer F et al. (1998) Combined arthroscopic and radiation synovectomy in rheumatoid arthritis. Orthopade 27: 188–196

    PubMed  Google Scholar 

  18. Kvien TK et al. (1987) Comparison of synovectomy and no synovectomy in patients with juvenile rheumatoid arthritis: a 24-month controlled study. Scand J Rheumatol 16: 81–91

    Article  CAS  Google Scholar 

  19. Nakamura H et al. (2000) The anti-rheumatic effect of multiple synovectomy in patients with refractory rheumatoid arthritis. Int Orthop 24: 242–245

    Article  CAS  Google Scholar 

  20. Herold N and Schroder HA (1995) Synovectomy and radial head excision in rheumatoid arthritis: 11 patients followed for 14 years. Acta Orthop Scand 66: 252–254

    Article  CAS  Google Scholar 

  21. Vahvanen V et al. (1991) Results of elbow synovectomy in rheumatoid arthritis. Arch Orthop Trauma Surg 110: 151–154

    Article  CAS  Google Scholar 

  22. Adams BD (2004) Surgical management of the arthritic wrist. Instr Course Lect 53: 41–45

    PubMed  Google Scholar 

  23. Ertel AN (1989) Flexor tendon ruptures in rheumatoid arthritis. Hand Clin 5: 177–190

    CAS  PubMed  Google Scholar 

  24. Bynum CK and Tasto J (2002) Arthroscopic treatment of synovial disorders in the shoulder, elbow, and ankle. J Knee Surg 15: 57–59

    PubMed  Google Scholar 

  25. Bohler N et al. (1985) Late results of synovectomy of wrist, MP and PIP joints: multicenter study. Clin Rheumatol 4: 23–25

    Article  CAS  Google Scholar 

  26. Vahvanen V and Patiala H (1984) Synovectomy of the wrist in rheumatoid arthritis and related diseases: a follow-up study of 97 consecutive cases. Arch Orthop Trauma Surg 102: 230–237

    Article  CAS  Google Scholar 

  27. Weiss RJ et al. (2007) Ankle/hindfoot arthrodesis in rheumatoid arthritis improves kinematics and kinetics of the knee and hip: a prospective gait analysis study. Rheumatology (Oxford) 46: 1024–1028

    Article  CAS  Google Scholar 

  28. Caron M et al. (1999) Tibiotalar joint arthrodesis for the treatment of severe ankle joint degeneration secondary to rheumatoid arthritis. Clin Podiatr Med Surg 16: 337–361

    CAS  PubMed  Google Scholar 

  29. Connor J and Nalebuff EA (1995) Current recommendations for surgery of the rheumatoid hand and wrist. Curr Opin Rheumatol 7: 120–124

    Article  CAS  Google Scholar 

  30. Herren DB and Ishikawa H (2005) Partial arthrodesis for the rheumatoid wrist. Hand Clin 21: 545–552

    Article  Google Scholar 

  31. Jaakkola JI and Mann RA (2004) A review of rheumatoid arthritis affecting the foot and ankle. Foot Ankle Int 25: 866–874

    Article  Google Scholar 

  32. O'Brien ET (1996) Surgical principles and planning for the rheumatoid hand and wrist. Clin Plast Surg 23: 407–420

    CAS  PubMed  Google Scholar 

  33. Kobus RJ and Turner RH (1990) Wrist arthrodesis for treatment of rheumatoid arthritis. J Hand Surg [Am] 15: 541–546

    Article  CAS  Google Scholar 

  34. Della Santa D and Chamay A (1995) Radiological evolution of the rheumatoid wrist after radio-lunate arthrodesis. J Hand Surg [Br] 20: 146–154

    Article  CAS  Google Scholar 

  35. Nelissen RG (2007) The lower limb in the rheumatoid arthritis patient: Focus on the hind, mid and forefoot and the ankle. Current Orthopaedics 21: 340–343

    Article  Google Scholar 

  36. Welch RB and Charnley J (1970) Low-friction arthroplasty of the hip in rheumatoid arthritis and ankylosing spondylitis. Clin Orthop Relat Res 72: 22–32

    CAS  PubMed  Google Scholar 

  37. Nelissen RG (2003) The impact of total joint replacement in rheumatoid arthritis. Best Pract Res Clin Rheumatol 17: 831–846

    Article  Google Scholar 

  38. Gough AK et al. (1994) Generalised bone loss in patients with early rheumatoid arthritis. Lancet 344: 23–27

    Article  CAS  Google Scholar 

  39. Simmen BR et al. (2005) Long-term results (more than 10 years) of the GSB III elbow prosthesis: 25 years of experience with a prosthesis semi-constraint with hinge [French]. Rev Chir Reparatrice Orthop Appar Mot 91 (Suppl 5): S73–S78

    Article  Google Scholar 

  40. van de Sande MA et al. (2006) Indications, complications, and results of shoulder arthroplasty. Scand J Rheumatol 35: 426–434

    Article  CAS  Google Scholar 

  41. Chmell MJ and Scott RD (1999) Total knee arthroplasty in patients with rheumatoid arthritis: an overview. Clin Orthop Relat Res 366: 54–60

    Article  Google Scholar 

  42. Kumar MN and Swann M (1998) Uncemented total hip arthroplasty in young patients with juvenile chronic arthritis. Ann R Coll Surg Engl 80: 203–209

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Goldfarb CA and Dovan TT (2006) Rheumatoid arthritis: silicone metacarpophalangeal joint arthroplasty indications, technique, and outcomes. Hand Clin 22: 177–182

    Article  Google Scholar 

  44. Chung KC et al. (2000) Patient outcomes following Swanson silastic metacarpophalangeal joint arthroplasty in the rheumatoid hand: a systematic overview. J Rheumatol 27: 1395–1402

    CAS  PubMed  Google Scholar 

  45. Mandl LA et al. (2002) Metacarpophalangeal arthroplasty in rheumatoid arthritis: what determines satisfaction with surgery? J Rheumatol 29: 2488–2491

    PubMed  Google Scholar 

  46. Shapiro JS (1996) The wrist in rheumatoid arthritis. Hand Clin 12: 477–498

    CAS  PubMed  Google Scholar 

  47. Flury MP et al. (1999) Rheumatoid arthritis of the wrist: classification related to the natural course. Clin Orthop 1: 72–77

    Article  Google Scholar 

  48. Ghattas L et al. (2005) Hand surgery in rheumatoid arthritis: state of the art and suggestions for research. Rheumatology (Oxford) 44: 834–845

    Article  CAS  Google Scholar 

  49. Egan M et al. Splints and orthoses in the treatment of rheumatoid arthritis. Cochrane Database of Systematic Reviews 2003, Issue 1. Art. No.: CD004018. 10.1002/14651858.CD004018

  50. Pagnotta A et al. (2005) Static wrist splint use in the performance of daily activities by individuals with rheumatoid arthritis. J Rheumatol 32: 2136–2143

    PubMed  Google Scholar 

  51. Goldhahn J et al. (2007) Functional staging and surgical intervention of the elbow and shoulder joints in a patient with rheumatoid arthritis. Nat Clin Pract Rheumatol 3: 112–117

    Article  Google Scholar 

  52. Levy O et al. (2004) Copeland surface replacement arthroplasty of the shoulder in rheumatoid arthritis. J Bone Joint Surg Am 86: 512–518

    Article  Google Scholar 

  53. Bishop JY and Flatow EL (2005) Humeral head replacement versus total shoulder arthroplasty: clinical outcomes—a review. J Shoulder Elbow Surg 14 (Suppl 1): S141–S146

    Article  Google Scholar 

  54. Kelly JD Jr and Norris TR (2003) Decision making in glenohumeral arthroplasty. J Arthroplasty 18: 75–82

    Article  Google Scholar 

  55. Chung KC et al. (2006) Reasons why rheumatoid arthritis patients seek surgical treatment for hand deformities. J Hand Surg [Am] 31: 289–294

    Article  Google Scholar 

  56. Anderson RJ (1996) The orthopedic management of rheumatoid arthritis. Arthritis Care Res 9: 223–228

    Article  CAS  Google Scholar 

  57. Stucki G and Grimby G (2004) Applying the ICF in medicine. J Rehabil Med 44 (Suppl): 5–6

    Article  Google Scholar 

  58. Wolff B et al. (2004) Identifying the concepts contained in outcome measures of clinical trials on four internal disorders using the International Classification of Functioning, Disability and Health as a reference. J Rehabil Med 36 (Suppl 44): S37–S42

    Article  Google Scholar 

  59. Hudak PL et al. for the Upper Extremity Collaborative Group (UECG) (1996) Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. Am J Ind Med 29: 602–608

    Article  CAS  Google Scholar 

  60. Katz WA and Rothenberg R (2005) Section 2: The importance of improving function in patients with pain. J Clin Rheumatol 11 (Suppl 2): S6–S9

    Article  Google Scholar 

  61. Jolles BM et al. (2005) A study compared nine patient-specific indices for musculoskeletal disorders. J Clin Epidemiol 58: 791–801

    Article  Google Scholar 

  62. Angst F et al. (2005) Comparison of rheumatic and post-traumatic elbow joints after total elbow arthroplasty: comprehensive and specific evaluation of clinical picture, function, and quality of life [German]. Orthopade 34: 794–800

    Article  CAS  Google Scholar 

  63. Angst F et al. (2008) Responsiveness of six outcome assessment instruments in total shoulder arthroplasty. Arthritis Rheum 59: 391–398

    Article  Google Scholar 

  64. Emery P (1994) Assessment of rheumatoid arthritis—a clinician's viewpoint. J Rheumatol Suppl 42: 20–24

    CAS  PubMed  Google Scholar 

  65. Dunbar RP and Alexiades MM (1998) Decision making in rheumatoid arthritis: determining surgical priorities. Rheum Dis Clin North Am 24: 35–54

    Article  CAS  Google Scholar 

  66. Gile JT et al. (2006) Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis. Arthritis Rheum 55: 333–337

    Article  Google Scholar 

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Acknowledgements

The program leading to the article was funded by the Georg and Bertha Schwyzer-Winiker foundation. The authors thank D Gross for assistance with preparation of the manuscript.

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Correspondence to Jörg Goldhahn.

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Simmen, B., Bogoch, E. & Goldhahn, J. Surgery Insight: orthopedic treatment options in rheumatoid arthritis. Nat Rev Rheumatol 4, 266–273 (2008). https://doi.org/10.1038/ncprheum0767

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