Preliminary reportAssociation of cholesteryl ester transfer protein activity and TaqIB polymorphism with lipoprotein variations in Japanese subjects
Section snippets
Subjects
The initial study population consisted of 862 unrelated Japanese patients (524 men and 338 women) attending hospitals registered for this project. A total of 234 patients (133 men and 101 women) were excluded due to the use of drugs affecting lipid metabolism, uncontrolled diabetes mellitus (HbA1C > 8%), or liver, renal, or thyroid disease. Sixteen subjects with homozygous CETP deficiency, 18 patients with familial hypercholesterolemia, and 3 patients with chylomicronemia were excluded. After
Results
Baseline demographic and lipid parameters are summarized in Table 1. Age was well matched and average BMI was normal in both groups, but men had a significantly higher average BMI than women. Prevalence of smokers, including exsmokers, daily drinkers, CAD, and hypertension was significantly higher in men than in women. For CETP, both activity (+15%) and mass (+24%) were significantly greater in women than in men (P < .001). Despite the elevated CETP activity, women had, on average, 31% higher
Discussion
In the present study, we found an inverse correlation between CETP and HDL-C, in particular for HDL2-C, and a positive correlation between CETP and LDL-C, both in men and women. In men, apoA-I and apoA-II, major protein constituents of HDL, were also negatively correlated with CETP. The positive correlation between CETP and LDL-C agreed with most previous studies.11, 12, 15, 18 However, the negative correlation between HDL-C is a controversial finding. Both Kark et al11 and Gudnason et al12
Acknowledgements
We are indebted to Japan Tobacco Inc for materials and equipment for CETP measurement, and help with the statistical analysis.
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2018, AtherosclerosisCitation Excerpt :Plasma CETP concentrations were measured for 73 participants from whom plasma was available with ELISA kits (DAIICHI CETP ELISA, Alpco, Salem, USA), according to the manufacturer's instructions. We measured CETP concentration instead of exogenous CETP activity, both of which are however highly correlated [26–28]. For histological scoring of the liver biopsies, Hematoxylin-eosin and Klatskin (Masson) trichrome stains were used to assess histopathology.
Study to assess whether waist circumference and changes in serum glucose and lipid profile are independent variables for the CETP gene
2014, Diabetes Research and Clinical PracticeCitation Excerpt :Importantly, we found a more pronounced “AO-protecting” effect in the D442G minor allele G. Considering that (1) there is an inverse association between the CETP minor allele and HDL mass [14,15], a lipoprotein that has a beneficial effect on clearance of accumulated cholesteryl esters from adipose tissue, and (2) that CETP functions in adipocytes to selectively uptake of HDL-derived cholesteryl esters, thus possibly contributing to adipocyte maturation [17], we conclude that the CETP gene polymorphisms that modulate the activity or concentration of CETP might be associated with increased adipose content in vivo. The results of this study support this hypothesis [25–27]. TG, Chol, HDL and LDL are well-known indicators of blood lipids and are used to assess the risk of many chronic diseases, including obesity-related disease [28–30].
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2012, Clinica Chimica ActaCitation Excerpt :With respect to CETP status in CAD, findings in the literature are controversial and CETP has been associated to either predisposition [17,18] and protection [19,20] against CAD. It has been assumed that CETP concentration in serum correlates well with CETP activity [21–23]. However, in a recent study by Kappelle et al. [24] CETP concentration was found equal in CAD and non-CAD subjects whereas the transfer of cholesteryl esters from HDL to the apo B-containing lipoproteins was increased in CAD.
Probucol markedly reduces HDL phospholipids and elevated preβ1-HDL without delayed conversion into α-migrating HDL: Putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling
2008, AtherosclerosisCitation Excerpt :In fact, probucol decreased the accentuated CE transfer to the normal level in one study [18], whereas it increased CE transfer in other studies [8,19]. Ikewaki et al. [20] measured the CETP mass in 591 Japanese subjects and examined the relationship between CETP mass and HDL-C; the correlation between them was significant, but very weak (r = − 0.173). We failed to detect a significant correlation between CETP mass and the HDL subfraction changes induced by probucol (Table 5).