Mechanisms of allergy and clinical immunologyDifferences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma
Section snippets
Patients
We recruited 38 patients with CSS, 20 patients with CEP with asthma, and 108 adult patients with general asthma (non-CSS and non-CEP) treated between January 2003 and May 2007 at the Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara, Kanagawa, Japan. All 108 adult patients with general asthma were given diagnoses according to the criteria of the Global Initiative for Asthma (GINA) guidelines,36 and the severity of their asthma was classified as
Clinical findings
There were more women than men with CSS and CEP, but there was no significant difference in the sex ratio among patients with asthma at any step. Thirty-eight patients with CSS and 15 of the 20 patients with CEP had been classified according to the GINA guidelines as having severe asthma at the first hospital visit (Table I). There was no significant difference in the age of onset of asthma between those who had CSS or CEP. Patients with CEP and asthma did not go on to have CSS during the
Discussion
CSS is a rare vasculitis with an annual incidence of approximately 2.4 to 6.8 cases per 1 million persons.40, 41 The report by Guillevin et al2 revealed some triggering factors that preceded the onset of the disease by up to several months, including desensitization, rapid discontinuation of oral corticosteroids, and vaccination. The cause and pathogenesis, and especially the heritability, of CSS are still unknown. In a rare case of familial CSS in 2 sisters, it was not possible to explain the
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Eosinophilic granulomatosis with polyangiitis: A review
2023, Autoimmunity ReviewsCitation Excerpt :TH1-mediated pathways seem to be responsible for granulomatosis, inflammation and vasculitis, as well as the neutrophilic inflammation found in these lesions [19,22]. Regulatory T cells' activity appear to be diminished in active disease, compared with quiescent EGPA [22,23]. Increased expression and secretion of eotaxin-3 by endothelial cells is associated with increased EGPA disease activity [18,24].
Eosinophilic Interstitial Pneumonia
2021, Encyclopedia of Respiratory Medicine, Second EditionPulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features
2020, American Journal of PathologyCitation Excerpt :The CCL18 and CCL13 chemokine pattern is novel in EGPA and differs from the finding that CCL17 and CCL22, made by respiratory epithelium, are dominant in asthma.30 The presence of CCL18 also explains the apparent discrepancy between the increase in Tregs found in the present study and earlier work by two different groups demonstrating decreased peripheral blood Tregs in EGPA.12–17,31 Although Saito and Tsurikisawa and colleagues12–17 concluded that Tregs have a protective effect in EGPA and are lost during active disease, these results suggest that, rather than being lost, Tregs are recruited to lung tissue, presumably by chemokine (C-C motif) ligand (CCL) 18, where they likely contribute to the immunoregulatory findings in EGPA.
Pathophysiology of eosinophilic granulomatosis with polyangitis (Churg-Strauss)
2016, Revue de Medecine InterneDividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis
2016, Autoimmunity Reviews
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.