Biochemical and Biophysical Research Communications
Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF☆
Section snippets
Materials and methods
Mouse embryos and neonatal mice. This study was approved by the Institutional Animal Care and Use Committee of the University of California, Davis, according to National Institutes of Health guidelines. Timed pregnant CD-1 mice were obtained from the Charles River Laboratories (Wilmington, MA) and kept at the animal facilities of University of California, Davis. The pregnant mice from 9.5 to 17.5 dpc and neonatal mice born at 19.5 dpc were euthanized by CO2 asphyxiation. Embryos and neonatal mice
IL-17B mRNA was expressed in mouse embryonic limb buds
IL-17 cytokines form a unique novel family, of which the prototype member IL-17A has been studied extensively [1], [2], [3], [4], [5], [6]. However, reports on IL-17B were very limited [10], [11], [12], [21]. Our finding that IL-17B was expressed in calf articular cartilage but not in adult cow cartilage led us to hypothesize that IL-17B is perhaps predominantly expressed in early stages of bone development. To test our hypothesis, we isolated total RNA from mouse embryonic limb buds and limbs
Acknowledgments
We thank Dr. T.K. Sampath, Creative BioMolecules, Hopkinton, MA, for his generous gift of BMP-7. This study was supported by a grant from the National Institutes of Health (5R01AR047345-02).
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Abbreviations: IL-17, interleukin-17; BMP-7, bone morphogenetic protein-7; bFGF, basic fibroblast growth factor; ERK, extracellular signal-regulated kinase; Sef, similar expression to fgf genes; PTHrP, parathyroid hormone-related protein.