A meeting reviewMacrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell?
Section snippets
Acknowledgements
The author would like to thank Dr. David D. Sherry for his critical review of this manuscript.
Take Home Messages:
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MAS/HLH is a life threatening complication of many autoimmune diseases that appears as a constellation of fever, cytopenia, lymphadenopathy, organomegaly, coaguloapthy, and CNS inflammation.
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MAS/HLH is caused by the lack of death of antigen presenting cells to terminate the immune response.
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Although a number of CD8+ T-cell defects have been described in primary HLH, it is unclear what
References (21)
- et al.
Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood
J Pediatr
(2006) - et al.
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder
Blood
(2004) - et al.
Hypercytokinemia in familial hemophagocytic lymphohistiocytosis
Blood
(1991) - et al.
Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis
Blood
(1997) - et al.
Heme oxygenase-1: unleashing the protective properties of heme
Trends Immunol
(2003) - et al.
Activation of the haemostatic system in children with juvenile rheumatoid arthritis correlates with disease activity
Thromb Res
(1998) - et al.
Reactive haemophagocytic syndrome in adult-onset Still's disease: a report of six patients and a review of the literature
Ann Rheum Dis
(2006) - et al.
Ankylosing spondylitis presenting with macrophage activation syndrome
Clin Rheumatol
(2007) - et al.
Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders
Arch Dis Child
(2001) - et al.
Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-{gamma}-producing lymphocytes and IL-6- and TNF-{alpha}-producing macrophages
Blood
(2004)
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