Original articleEpidemiologicalPrevalence of Hyperuricemia and its Relationship with Metabolic Syndrome in Thai Adults Receiving Annual Health Exams
Introduction
Hyperuricemia is commonly detected in subjects with abnormal purine metabolism, including overproduction of uric acid and insufficient uric acid excretion from the kidney (1). Prolonged hyperuricemia, often associated with gout, is an important risk factor for damaged joint (2). Hyperuricemia has been shown to be associated with several components of metabolic syndrome (MetS) and investigators have postulated that increased concentrations of uric acid may be another important component of the syndrome (3). In some epidemiologic studies, a close relationship between hyperuricemia and hypertension, insulin resistance and cardiovascular disease risk factors (such as obesity and smoking) has been reported 4, 5, 6, 7. Hyperuricemia is diagnosed in 5–30% of the general population, although the prevalence is higher among some ethnic groups (e.g., Japanese) and appears to be increasing worldwide (8). Serum uric acid concentrations are known to increase with age and are further increased after menopause in women (9). Considering current increases in the incidence and prevalence of obesity and MetS worldwide, as well as emerging evidence documenting associations between hyperuricemia and cardiovascular complications, Conen and colleagues have called for increased emphasis to be placed on understanding the epidemiological characteristic of hyperuricemia in developing countries (4).
Little information, however, exists concerning the prevalence and epidemiological characteristics of hyperuricemia in Thailand. We, therefore, conducted the present study to estimate the prevalence of hyperuricemia among Thai men and women receiving routine health examinations. We also sought to evaluate the extent to which, if at all, serum uric acid concentrations were associated with the risk of MetS.
Section snippets
Study Population and Data Collection
We conducted a cross-sectional study of 1,381 patients (376 men and 1,005 women) who first participated in annual health examinations at the Preventive Medicine Clinic of the King Chulalongkorn Memorial Hospital in Bangkok, Thailand during the period of July 1999 through February 2000. Participants were those with no previously diagnosed diabetes mellitus, hypertension, or gout and were not taking uric acid-, lipid- or blood pressure-lowering medication. During routine clinic visits
Results
Overall, the prevalence of hyperuricemia was 10.6% in this study population. Hyperuricemia was more common in men than in women (18.4 vs. 7.8%) (Table 1). Men with hyperuricemia, as compared to those without the condition, were older (p = 0.001), were more likely to have reported smoking (p = 0.019), and were former consumers of alcohol (p = 0.184). Women with hyperuricemia as compared with their counterparts without the condition were older (p <0.001), less well educated (p = 0.004) and were
Discussion
The 10.6% prevalence of hyperuricemia noted among Thai men and women in our study is higher than estimates reported for several other populations. For instance, Al-Arfaj and colleagues reported that the prevalence of hyperuricemia was 8.4% among Saudi men and women (15). Notably, hyperuricemia was defined using the same criteria for both studies. The prevalence of hyperuricemia in our study population is lower, however, than estimates reported for Japanese men and women who participated in a
Acknowledgments
This research was supported by Rachadapiseksompoj Faculty of Medicine Research Fund, Chulalongkorn University, Thailand, and National Institutes of Health. The research was completed while Dr. Vitool Lohsoonthorn was a Teaching Assistant-Consultant in Thailand for the 2005 Multidisciplinary International Research Training (MIRT) fellows. The MIRT Program of the University of Washington, School of Public Health and Community Medicine is supported by awards from the National Institutes of Health
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