Clinical Research StudySmoking and the Risk of Psoriasis in Women: Nurses’ Health Study II
Section snippets
Methods
The Nurses Health Study II (NHS II) is an ongoing longitudinal study of 116,608 female registered nurses between the ages of 25 and 42 years at baseline. Participants from 15 states completed and returned an initial questionnaire in 1989. The NHS II focuses on women’s health outcomes in a population younger than the original Nurses’ Health Study I cohort. The NHS II is followed with biennial questionnaires and the follow-up rate exceeds 90% for each 2-year period. In 2005, we asked participants
Baseline Characteristics
We documented 887 incident cases of psoriasis during the 14 years of follow-up. The baseline characteristics of the cohort according to smoking status are shown in Table 1. Alcohol consumption tended to increase from the never to the current smoker group, as did duration of smoking and number of cigarettes smoked per day. Current smokers were more likely to have been exposed to passive smoking than were never and past smokers.
Smoking Status, Intensity, Duration, and Risk of Incident Psoriasis
Compared with those who never smoked, the multivariate RR for
Discussion
Our objective was to prospectively evaluate the relation between smoking and the incidence of psoriasis in a large cohort of women. We found that both past and current smokers were at increased risk for developing psoriasis, and the risk was greater for current smokers. The risk was graded and increased with the duration, intensity, and pack-years of smoking. Furthermore, the risk of incident psoriasis decreased with increasing years of smoking cessation reaching nearly that of never smokers 20
Acknowledgments
We thank the participants in the Nurses Health Study II for their dedication and continued participation; the entire staff of the Nurses Health Study II; and Rong Chen, for her assistance with programming.
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This study was supported in part by grant 5 T32 AR007258-29 from the NIH and by Nurses’ Health Study II grant CA50385.