Clinical research studyPrevalence of the Metabolic Syndrome in Individuals with Hyperuricemia
Section snippets
Study Population
Conducted between 1988 and 1994, the NHANES III included a representative sample of the non-institutionalized US civilian population, which was selected using a multistage, stratified sampling design. Persons 60 years and older and African American and Mexican American persons were oversampled. In the current study, we analyzed data for 8669 men and nonpregnant women aged at least 20 years who attended the medical examination, had fasted at least 8 hours before the blood collection, and had
Results
The mean age of the study sample was 44 years, 50% were male, 76% were white, and the mean BMI was 26.5 kg/m2. The mean uric acid level was 5.42 mg/dL (95% CI, 5.37-5.46 mg/dL). There was a graded increase in the prevalence of the metabolic syndrome according to the revised NCEP/ATP III criteria among individuals with increasing levels of serum uric acid, up to 70% (95% CI, 51.4-89.9) among individuals with serum uric acid level of 10 mg/dL or greater (Table 1). Similarly, the increasing trend
Discussion
In this nationally representative sample of men and women, we found that there was a graded increase in the prevalence of the metabolic syndrome among individuals with increasing levels of hyperuricemia, up to 70% among individuals with the highest serum uric acid levels (≥10 mg/dL). This prevalence was approximately 4 times that among adults with the lowest serum uric acid levels (<6 mg/dL). The increasing prevalence of individual metabolic abnormalities with increasing levels of hyperuricemia
Conclusion
These findings from a nationally representative sample of US adults indicate that the prevalence of the metabolic syndrome increases substantially with increasing serum uric acid levels. These prevalence estimates should be reflected in an index of clinical suspicion for the concomitant presence of the metabolic syndrome. Physicians should recognize the metabolic syndrome as a frequent comorbidity of hyperuricemia and treat it to prevent serious complications.
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