Invited Review ArticleIs the cardioprotective effect of alcohol real?
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Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy
2018, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pathogenesis of alcoholic cardiomyopathy [12,21,53,95], beneficial effects of the antioxidant components of red wine were hardly recapitulated in humans [4,6]. Given the apparent changes in autophagy in alcoholic cardiomyopathy and overwhelming knowledge of targeting autophagy in the management of cardiovascular diseases [10,21,26,33,63], further study is warranted to better understand the precise role of excessive autophagy (autosis) and regulation of autophagy by ethanol, acetaldehyde and oxidative stress in the pathogenesis and therapeutics of alcoholic cardiomyopathy.
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