REGULAR ARTICLEEnhanced Platelet Sensitivity to Prostacyclin in Patients in an Active Stage of Takayasu Arteritis
Section snippets
Patient Selection
Twenty-two Japanese patients with TA and 12 gender- and age-matched control subjects entered this study after informed consent. All 22 patients were female, and met the diagnostic criteria for TA based on the report by the American College of Rheumatology [11]. Subject clinical characteristics are summarized in Table 1. Of the 22 patients, 12 were diagnosed as having active disease at the time of the study and the remaining 10 as having inactive disease. Active disease was defined primarily
Platelet Aggregation and Plasma Prostanoids
Fig. 1 shows collagen-induced platelet aggregation in patients with TA and the controls as demonstrated by EC50 values. Although EC50 values in patients with inactive disease were similar to those of the controls, those in patients with active disease were significantly lower, suggesting enhanced platelet aggregation. In accordance with this in vitro finding, plasma TXB2 levels were also found to be increased only in patients with active disease (Fig. 2, top panel). Conversely, in patients with
Discussion
Thrombogenic tendency in TA has been discussed by some reports in regards to coagulation, fibrinolysis and platelet function. Akazawa et al. reported that plasma levels of platelet factor 4, β-thromboglobulin, thrombin-antithrombin III complex and fibrinopeptide A were significantly increased in patients with TA, though they found no differences between active (ESR≥20 mm Hg) and inactive (ESR<20 mm Hg) patients [6]. In the present study, we also confirmed elevation of plasma TXB2, another
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Analysis of clinical features between active and inactive patients of Takayasu's arteritis with pulmonary arteries involvement
2023, International Journal of CardiologyCoronary involvement in Takayasu's arteritis
2007, Autoimmunity ReviewsCitation Excerpt :Even without antiphospholipid antibodies patients with active TA experience thrombosis of affected vessels. One study underlined the increased sensitivity of platelets to collagen and the increased plasma thromboxane B2 concentration as possible causes of such occurrence [22]. Several studies have demonstrated beneficial effects of low dose aspirin on ischemic complications of giant cell arteritis that manifest as visual loss and cerebrovascular accidents [23,24].
Platelet count as a potential predictor in refractory Takayasu arteritis
2023, Rheumatology InternationalPan American League of Associations for Rheumatology Guidelines for the Treatment of Takayasu Arteritis
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