IL-10 inhibits the adhesion of leukocytic cells to IL-1-activated human endothelial cells
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Cited by (86)
Local IL-10 replacement therapy was effective for steroid-insensitive asthma in mice
2022, International ImmunopharmacologyCitation Excerpt :These data suggested that intratracheal administered IL-10 down-regulated the expressions of ICAM-1 and VCAM-1 on pulmonary vascular endothelial cells via binding to IL-10R1, leading to the inhibition of eosinophilic and neutrophilic infiltrations. Indeed, Krakauer demonstrated that IL-10 downregulated the expressions of VCAM-1 and ICAM-1 on IL-1-activated human endothelial cells, followed by inhibiting the adhesion of leukocytes [43]. Other groups also reported that IL-10 significantly decreased VCAM-1 [44] and ICAM-1 [45] protein levels in mouse cerebrovascular endothelial cells and human coronary artery endothelial cells, respectively.
Design and development of Branched Poly(ß-aminoester) nanoparticles for Interleukin-10 gene delivery in a mouse model of atherosclerosis
2022, Acta BiomaterialiaCitation Excerpt :As such, the VCAM-1 function has also been targeted to reduce the accumulation of inflammatory cells to the plaque [34]. Decreasing VCAM-1 expression at the plaque may thus prove a viable therapeutic option and a possible outcome of anti-inflammatory therapy utilizing IL-10 [35]. Herein, we report on a follow-up study emphasizing on in vivo investigations of our IL-10 gene delivery system, as an additional step towards its clinical translation.
miR-374b-5p is increased in deep vein thrombosis and negatively targets IL-10
2020, Journal of Molecular and Cellular CardiologyOrf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin
2016, Virus ResearchCitation Excerpt :Both cellular and viral IL-10 have been shown to inhibit the production of chemokines, such as CCL2, CCL3, and CCL5 (Imlach et al., 2002; Wise et al., 2007, 2014), which are key chemoattractants for monocytes, mast cells and DC (Sabatté et al., 2007; Shi and Pamer, 2011; Halova et al., 2012). Also the IL-10s suppress production of cytokines such as TNF and IL-1β (Imlach et al., 2002; Wise et al., 2007, 2014), which stimulate endothelial cell expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and the extravasation of immune cells (Krakauer, 1995; Kawachi et al., 2000). Moreover, cellular IL-10 can down regulate the expression of adhesion molecules on immune cells including l-selectin and β2-integrin (Inoue, 2000; Mtairag et al., 2001).