Prostaglandin D2 metabolite stimulates collagen synthesis by human osteoblasts during calcification
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Amplification by tramadol of PGD<inf>2</inf>-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter
2021, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :Among them, PGD2 has been originally recognized to be involved in regulating the osteoclast function to bone anabolism [15]. It has been reported in later that PGD2 induces the calcification-associated collagen synthesis in osteoblasts [16]. In addition, PGD2 released from osteoblasts reportedly modulates the expression of osteoprotegerin as well as RANKL in themselves [17].
Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase
2019, Prostaglandins and Other Lipid MediatorsCitation Excerpt :The inconsistency of the responsibility to PGD2 presented in Figs. 1 and 2 was probably due to the acceptable differences in cell conditions in vitro (eg. cell passages). We have previously demonstrated that PGD2 stimulates HSP27 induction at least in part through the activation of SAPK/JNK and p38 MAP kinase in osteoblast-like MC3T3-E1 cells [12,13]. To clarify whether the activation of SAPK/JNK is involved in the enhancement by HSP90 inhibitors of the PGD2-elicited HSP27 induction or not, we next examined the effects of HSP90 inhibitors on the phosphorylation of SAPK/JNK stimulated by PGD2 in MC3T3-E1 cells.
The therapeutic potential of CRTH2/DP2 beyond allergy and asthma
2017, Prostaglandins and Other Lipid MediatorsCitation Excerpt :Supporting this pro-inflammatory role of CRTH2 in IBD, timapiprant significantly reduced eosinophil infiltration in the tissue and induced some clinical improvement in eosinophilic esophagitis patients [28]. Interestingly, PGD2 can potently modulate bone metabolism with its capacity to induce collagen synthesis during the process of calcification [72] and IL-6 secretion by osteoblasts [73]. In 2005, Gallant and colleagues described both the production of PGD2 by, and the presence of both DP1 and CRTH2 receptors on, human osteoblasts.
PGD<inf>2</inf> stimulates osteoprotegerin synthesis via AMP-activated protein kinase in osteoblasts: Regulation of ERK and SAPK/JNK
2015, Prostaglandins Leukotrienes and Essential Fatty AcidsSuppression by resveratrol of prostaglandin D<inf>2</inf>-stimulated osteoprotegerin synthesis in osteoblasts
2014, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :Among them, prostaglandin D2 (PGD2) is recognized to be implicated in the control of osteoclast function and bone anabolism [6]. It has been shown that PGD2 stimulates collagen synthesis during calcification of osteoblasts [7]. In addition, PGD2 produced by osteoblasts reportedly modulates expression of OPG and RANKL in osteoblasts [8].
The role of vitamin D in human fracture healing: A systematic review of the literature
2014, BoneCitation Excerpt :Zhou et al. [85] showed that in bone marrow cells from vitamin D deficient patients vitamin D supplementation resulted in a greater stimulation of osteoblastogenesis than in bone marrow cells from vitamin D sufficient patients. The production of collagen I, the major component of the extracellular matrix, by osteoblastic cell cultures is stimulated by vitamin D [55,82,86], although no effect was found in other in vitro studies [55,87,88]. The production of osteocalcin and osteopontin (noncollagenous matrix proteins) by osteoblasts is stimulated by vitamin D [55].