Association of psychiatric manifestations with antibodies to ribosomal p proteins in systemic lupus erythematosus☆
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Cited by (241)
Tissue resident cell processes determine organ damage in systemic lupus erythematosus
2022, Clinical ImmunologyThe immunologic etiology of psychiatric manifestations in systemic lupus erythematosus: A narrative review on the role of the blood brain barrier, antibodies, cytokines and chemokines
2020, Autoimmunity ReviewsCitation Excerpt :However, more convincing evidence concerning the association between anti-RP in serum/CSF, depression and psychosis suggests a role for anti-RP in the pathogenesis of these NPSLE manifestations by mediating concentration dependent neuronal dysfunction or apoptosis. Several studies demonstrated a correlation between anti-RP in serum or CSF, psychiatric NPSLE [18,23,80,102,113,118,122,23,138,151] and more specifically depression [23,80,120,124–126] and lupus psychosis [80–82,109,119–121,124–135,152]. An important number of studies (N=20) could not confirm the association between anti-RP in serum or CSF and psychiatric NPSLE as a group [81,82,96,98,111,112,115,132,134,137,139–147,151], though considerably fewer studies disputed the association between serum anti-RP, depression [110,148–150] and psychosis [113,136,149,150].
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
2020, NeuronCitation Excerpt :Thus, a high titer of anti-phospholipid antibodies was found in 63 depressed patients compared to healthy controls (Gorman and Cummings, 1993; Maes et al., 1993). In addition, the presence of anti-ribosomal-P antibodies has been associated with depression and psychosis in patients with lupus erythematosus (Nojima et al., 1992; Schneebaum et al., 1991; Tzioufas et al., 2000; Watanabe et al., 1996). Furthermore, CSF anti-N-methyl-D-aspartate receptor NR2 antibodies are elevated in systemic lupus erythematosus patients with active neuropsychiatric manifestations, and these are associated with BBB damage (Hirohata et al., 2014), whereas only the serum level of anti-Sm antibodies but not serum levels of anti-NR2, anti-P, or anti-phospholipid antibodies contributes to the BBB disruption in these patients (Hirohata et al., 2018).
The diagnosis and clinical management of the neuropsychiatric manifestations of lupus
2016, Journal of AutoimmunityCitation Excerpt :see Table 5: Association between Abs and specific neuropsychiatric syndromes). Compared with SLE patients, NPSLE patients are more likely to have elevated serum levels of LA, APL, aCL [23,27,37,63,70,84,84,89,136,136,172,179–185], anti-Rib-P Abs [63,136,141–144,146,149,150,153,172,179,180,184,186–189] and increased CSF levels of anti-neuronal Abs [136,184,190–194]. Table 5 summarizes the common association between NPSLE clinical pictures and single Abs positivity or combined Abs positivity.
The importance of cytokines and autoantibodies in depression
2015, Autoimmunity Reviews
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This work was supported in part by Grants AR 37070 and AI-28495 from the National Institutes of Health.
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Dr. Schneebaum's current address: Division of Rheumatology, Lahey Clinic Medical Center, 41 Mall Road, Burlington, Massachusetts 01805.