Clinical studyEvaluation of monoclonal gammopathies in the “well” elderly☆
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Cited by (123)
Monoclonal gammopathy associated neuropathy: Focusing on IgM M-protein associated neuropathy
2020, Dysimmune NeuropathiesClinical electrophysiology of axonal polyneuropathies
2019, Handbook of Clinical NeurologyCitation Excerpt :This section discusses primary systemic amyloidosis and MGUS, both of which are associated with an axonal sensorimotor polyneuropathy. The most common paraproteinemic axonal neuropathy is associated with MGUS, a condition estimated to be present in 5% of those 70 years or older (Crawford et al., 1987). Overall, peripheral neuropathy is seen with all subtypes of Ig gammopathy but is most frequent with IgM gammopathy (48%) (Rajabally, 2011).
Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy
2015, Journal of the Neurological SciencesCitation Excerpt :MGUS is the most common monoclonal gammopathy [1–3]. The prevalence of monoclonal gammopathy rises with age reaching 3–10% among those over 70 years of age [4,5], while MGUS has a prevalence of 3% in subjects over 50 years of age [3]. For several decades an association between monoclonal gammopathy and peripheral neuropathy has been suspected, especially between MGUS and peripheral neuropathy [1,2].
Clinical Immunology: Immune Senescence and the Acquired Immune Deficiency of Aging
2010, Brocklehurst's Textbook of Geriatric Medicine and GerontologyDiagnostic and Prognostic Value of PACAP in Multiple Myeloma
2023, International Journal of Molecular Sciences
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This work was support in part by the Geriatric Fellowship Program and the General Medicine Research Service of the Veterans Administration.