Clinical study
Clinical significance of anti-Sm antibodies in systemic lupus erythematosus

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Abstract

Case records of 34 patients with systemic lupus erythematosus (SLE) were analyzed. Twelve patients had both anti-DNA and anti-Sm antibodies (Group I) and 22 had anti-DNA antibodies only (Group II). The disease patterns were comparable, except for (1) cutaneous vasculitis, which was observed in six of 12 patients in Group I and one of 22 in Group II (p < 0.01); (2) pulmonary manifestations, nine of 12 in Group I and two of 22 in Group II (p < 0.001); (3) cardiac manifestations, eight of 12 in Group I and four of 22 in Group II (p < 0.01); and (4) renal biopsy, which showed milder lesions in Group I than in Group II (p < 0.05). Evolution was fatal in four patients in Group I and in none in Group II. It is suggested that in SLE, the presence of anti-Sm antibody is associated with a much higher incidence of vasculitis, resulting in peculiar visceral manifestations, which can be poorly responsive to therapy. Whether there is a direct association between anti-Sm antibody and vasculitis or whether the common denominator is a genetic selection remains to be determined.

References (28)

  • AS Cohen et al.

    Preliminary criteria for the classification of systemic lupus erythematosus

    Bull Rheum Dis

    (1971)
  • AP Peltier et al.

    Détection des anticorps anti DNA du sérum par la méthode radio-immunologique de Farr

    Nouv Presse Med

    (1974)
  • M Beaufils et al.

    Glomerulonephritis in severe bacterial infections with and without endocarditis

    Adv Nephrol

    (1977)
  • EM Tan et al.

    Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus

    J Immunol

    (1966)
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    From the Departments of Nephrology and Rheumatology, Hôpital Tenon, Paris, France.

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