Clinical studyRenal outcomes of gout and hyperuricemia☆
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Cited by (137)
Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review
2017, Journal of Advanced ResearchClinical Features and Treatment of Gout
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionEpidemiology of gout
2014, Rheumatic Disease Clinics of North AmericaCitation Excerpt :The association between gout and renal disease is complex and could be bidirectional, that is, although renal disease predisposes to the development of gout, gout and its treatment are themselves thought to lead to renal impairment and chronic kidney disease. Such associations have been recognized for many years, yet early studies were undertaken in specialist secondary care populations,74–76 which may not be representative of most patients with gout who are managed exclusively in primary care. More recently, 2 population-based epidemiologic studies have provided convincing evidence that renal disease is a risk factor for gout.
Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish heart health extended cohort study
2014, AtherosclerosisCitation Excerpt :Despite accounting for only a small proportion of deaths (5.6%), we found that uric acid was highly predictive of kidney-related mortality independent of eGFR. These findings are distinct from other observational studies [61,62]. Although uric acid is highly associated with existing kidney injury [27,29], its relationship with kidney disease is controversial.
Management of asymptomatic hyperuricemia: Integrated Diabetes & Endocrine Academy (IDEA) consensus statement
2020, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :Untreated hyperuricemia is also a risk factor for renal calculi. In a study of 1386 subjects with asymptomatic hyperuricemia followed up for 10 years showed that 0.3% of patients with asymptomatic hyperuricemia developed renal calculi as compared to 0.1% in normouricemic patients [15]. A study on Korean population found that there was a linear relationship between elevated sUA and the risk of developing nephrolithiasis in males which was 1.06 (95% CI, 1.02–1.11) when sUA was 7.0–7.9 mg/dl, which increased to 1.72 (95% CI, 1.44–2.06) for a sUA ≥10 mg/dl [16].
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This research was supported by the Community Service Program of Kaiser Foundation Hospitals.
- 1
From the Division of Rheumatology, Department of Medicine, Kaiser-Permanente Medical Center, San Francisco, California.