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Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases

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Abstract

Given that Lactobacillus has been reported to be the causative pathogen in many types of infection despite debate regarding the organism’s clinical significance, a literature review was conducted to investigate the treatments and outcomes of Lactobacillus infections reported to date. In this article, the characteristics of over 200 reported cases of Lactobacillus-associated infections are summarized. Lactobacillus was found to be frequently associated with endocarditis and bacteremia. Lactobacillus was also associated with a variety of other infections including, but not limited to, peritonitis, abscesses, and meningitis. The species casei and rhamnosus were the most common. The isolates tended to be most sensitive to erythromycin and clindamycin and most resistant to vancomycin. The species that was most sensitive to vancomycin was acidophilus. The overall mortality rate was nearly 30%. There was a significant association between mortality and polymicrobial infection (P=0.004). In the subset of patients with bacteremia, increased mortality was associated with inadequate treatment (P=0.001) and polymicrobial bacteremia (P=0.044).

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  1. Edward Hines, Jr. VA Hospital, Pharmacy Service, 119 5th Avenue and Roosevelt Road, Hines, IL 60141, USA

    J. P. Cannon

  2. Midwest Center for Health Services and Policy Research, Edward Hines, Jr. VA Hospital, PO Box 5000 (151-H), Hines, IL 60141, USA

    T. A. Lee

  3. Center for Healthcare Studies, Division of General Internal Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Chicago, IL 60611, USA

    T. A. Lee

  4. Center for Pharmacoeconomic Research, College of Pharmacy, 833 South Wood Street (Mail Code 886), University of Illinois at Chicago, Chicago, IL 60612, USA

    T. A. Lee

  5. Department of Pharmacy Practice, College of Pharmacy, 833 South Wood Street (Mail Code 886), University of Illinois at Chicago, Chicago, IL 60611, USA

    L. H. Danziger

  6. Department of Medicine, Section of Infectious Diseases, University of Illinois at Chicago, Chicago, IL 60612, USA

    J. T. Bolanos

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Cannon, J.P., Lee, T.A., Bolanos, J.T. et al. Pathogenic relevance of Lactobacillus: a retrospective review of over 200 cases. Eur J Clin Microbiol Infect Dis 24, 31–40 (2005). https://doi.org/10.1007/s10096-004-1253-y

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