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The SAPHO syndrome: a clinical and imaging study

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Abstract

The purpose of this study is to describe the clinical and radiological manifestations of patients with the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Retrospective study (1984–2007) was performed in a single center. All patients with the SAPHO syndrome were included. Fifty-two patients were included: 26 male, mean age at diagnosis is 42±12 years. Ostearticular involvement was present before cutaneous involvement in 59.6% of patients and concomitantly in 23.5%. Anterior chest pain was the commonest clinical manifestation, it was present in 38 patients (73%), followed by peripheral arthritis in 17 patients (32%), and sacroliliac pain in 14 patients (26.9%). Cutaneous involvement was present in 33 patients (63.5%). HLA B27 antigen was present in eight patients (17.7%). Bone scintigraphy showed an increased uptake in 42 patients (93.3%). The location of the uptake was mainly in sternoclavicular and manubriosternal joints. CT scan was performed in all “hot joints” showing sclerosis, erosions, hyperostosis, and soft tissue involvement. Refractory patients were treated mainly with pamidronate. Although SAPHO syndrome is an entity that share features that fit into a variety of established disease categories, the present study has a homogenous clinical and radiological pattern that gives support to believe that the SAPHO syndrome is an isolated clinical entity.

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Authors and Affiliations

  1. Rheumatology Section, Althaia, Avg. Bases de Manresa 6-8, Manresa, 08242, Spain

    Meritxell Sallés

  2. Rheumatology Section, Hospital Universitari Germans Trias i Pujol, Crta Canyet sn, Badalona, 08916, Spain

    Alejandro Olivé, Susana Holgado, Lourdes Mateo & Xavier Tena

  3. Radiology Service, Hospital Universitari Germans Trias i Pujol, Crta Canyet sn, Badalona, 08916, Spain

    Ricard Perez-Andres

  4. Rheumatology Section, Mutua Terrassa, Mutua Terrassa, Spain

    Elena Riera

Authors
  1. Meritxell Sallés
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  2. Alejandro Olivé
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  3. Ricard Perez-Andres
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  4. Susana Holgado
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  5. Lourdes Mateo
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  6. Elena Riera
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  7. Xavier Tena
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Correspondence to Meritxell Sallés or Alejandro Olivé.

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Sallés, M., Olivé, A., Perez-Andres, R. et al. The SAPHO syndrome: a clinical and imaging study. Clin Rheumatol 30, 245–249 (2011). https://doi.org/10.1007/s10067-010-1560-x

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  • DOI: https://doi.org/10.1007/s10067-010-1560-x

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