Abstract
The aim of this study was to evaluate neurological manifestations of primary Sjögren’s syndrome (pSS) and investigate the etiology and pathogenesis of peripheral and central nervous complications in pSS. Thirty-two patients with pSS were enrolled in the present study, 20 of whom had neurological involvement plus sicca symptoms. The clinical features were evaluated by neurological examinations including nerve conduction study, magnetic resonance imaging, cerebrospinal fluid, and electroencephalogram. The frequency of fever was significantly higher (P = 0.006) in pSS with neurological involvement than in pSS without neurological involvement. There was no statistical significance in other factors between the two groups. Peripheral nervous system (PNS), central nervous system (CNS), and both PNS and CNS involvements were revealed in 14, 3, and 3 patients, respectively. Optic neuritis and trigeminal neuralgia were revealed frequently in cranial neuropathy. Anti-aquaporin 4 antibody was detected in one patient with optic neuritis. Of the nine patients with polyneuropathy, eight patients presented pure sensory neuropathy including small fiber neuropathy (SFN). pSS with SFN appeared to have no clinically abnormal features, including muscle weakness and decreasing deep tendon reflex. Skin biopsy revealed epidermal nerve fiber degenerated in one pSS patient with pure sensory neuropathy who was diagnosed as having SFN. Our observations suggest that a number of mechanisms can be attributed to neurological involvements in pSS rather than just the mechanisms previously described (i.e., vasculitis and ganglioneuronitis). Presumably, specific autoantibodies may directly induce injury of the nervous system.
Similar content being viewed by others
References
Alexander E, Provost T, Stevens M, Alexander G (1982) Neurologic complications of primary Sjögren’s syndrome. Medicine (Baltimore) 61(4):247–257
Griffin J, Cornblath D, Alexander E, Campbell J, Low P, Bird S et al (1990) Ataxic sensory neuropathy and dorsal root ganglionitis associated with Sjögren’s syndrome. Ann Neurol 27(3):304–315
Mellgren S, Conn D, Stevens J, Dyck P (1989) Peripheral neuropathy in primary Sjögren’s syndrome. Neurology 39(3):390–394
Hebbar M, Hebbar-Savean K, Hachulla E, Brouillard M, Hatron P, Devulder B (1995) Participation of cryoglobulinaemia in the severe peripheral neuropathies of primary Sjögren’s syndrome. Ann Med Interne (Paris) 146(4):235–238
Alexander E, Ranzenbach M, Kumar A, Kozachuk W, Rosenbaum A, Patronas N et al (1994) Anti-Ro(SS-A) autoantibodies in central nervous system disease associated with Sjögren’s syndrome (CNS-SS): clinical, neuroimaging, and angiographic correlates. Neurology 44(5):899–908
Lecky B, Hughes R, Murray N (1987) Trigeminal sensory neuropathy. A study of 22 cases. Brain 110(Pt 6):1463–1485
Satake M, Yoshimura T, Iwaki T, Yamada T, Kobayashi T (1995) Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren’s syndrome. J Neurol Sci 132(2):122–125
Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H et al (2005) The wide spectrum of clinical manifestations in Sjögren’s syndrome-associated neuropathy. Brain 128(Pt 11):2518–2534
Hoitsma E, Reulen J, de Baets M, Drent M, Spaans F, Faber C (2004) Small fiber neuropathy: a common and important clinical disorder. J Neurol Sci 227(1):119–130
Al-Shekhlee A, Chelimsky T, Preston D (2002) Review: small-fiber neuropathy. Neurologist 8(4):237–253
Chai J, Herrmann D, Stanton M, Barbano R, Logigian E (2005) Painful small-fiber neuropathy in Sjogren syndrome. Neurology 65(6):925–927
Wakasugi D, Kato T, Gono T, Ito E, Nodera H, Kawaguchi Y et al (2009) Extreme efficacy of intravenous immunoglobulin therapy for severe burning pain in a patient with small fiber neuropathy associated with primary Sjögren’s syndrome. Mod Rheumatol 19:437–440
Alexander E, Malinow K, Lejewski J, Jerdan M, Provost T, Alexander G (1986) Primary Sjögren's syndrome with central nervous system disease mimicking multiple sclerosis. Ann Intern Med 104(3):323–330
Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M et al (2007) Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 130(Pt 5):1235–1243
Wingerchuk D, Hogancamp W, O'Brien P, Weinshenker B (1999) The clinical course of neuromyelitis optica (Devic’s syndrome). Neurology 53(5):1107–1114
Wingerchuk D, Lennon V, Lucchinetti C, Pittock S, Weinshenker B (2007) The spectrum of neuromyelitis optica. Lancet Neurol 6(9):805–815
Vitali C, Bombardieri S, Jonsson R, Moutsopoulos H, Alexander E, Carsons S et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American–European Consensus Group. Ann Rheum Dis 61(6):554–558
McArthur J, Stocks E, Hauer P, Cornblath D, Griffin J (1998) Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol 55(12):1513–1520
Delalande S, de Seze J, Fauchais A, Hachulla E, Stojkovic T, Ferriby D et al (2004) Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore) 83(5):280–291
Gøransson L, Brun J, Harboe E, Mellgren S, Omdal R (2006) Intraepidermal nerve fiber densities in chronic inflammatory autoimmune diseases. Arch Neurol 63(10):1410–1413
Lopate G, Pestronk A, Al-Lozi M, Lynch T, Florence J, Miller T et al (2006) Peripheral neuropathy in an outpatient cohort of patients with Sjögren’s syndrome. Muscle Nerve 33(5):672–676
Moll J, Markusse H, Pijnenburg J, Vecht C, Henzen-Logmans S (1993) Antineuronal antibodies in patients with neurologic complications of primary Sjögren’s syndrome. Neurology 43(12):2574–2581
Waterman S, Gordon T, Rischmueller M (2000) Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren’s syndrome. Arthritis Rheum 43(7):1647–1654
Smith A, Jackson M, Wang F, Cavill D, Rischmueller M, Gordon T (2005) Neutralization of muscarinic receptor autoantibodies by intravenous immunoglobulin in Sjögren syndrome. Hum Immunol 66(4):411–416
Orman B, Sterin-Borda L, De Couto Pita A, Reina S, Borda E (2007) Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis. Int Immunopharmacol 7(12):1535–1543
Ishida K, Uchihara T, Mizusawa H (2007) Recurrent aseptic meningitis: a new CSF complication of Sjogren’s syndrome. J Neurol 254(6):806–807
Acknowledgments
We would like to thank Dr. Hiroyuki Nodera for staining of the skin biopsies and Dr. Toshiyuki Takahashi, Yasuto Itoyama, and Keiko Tanaka for detection of the anti-aquaporin 4 antibody. This study was supported by research grants from the Ministry of Health, Labour and Welfare in Japan.
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gono, T., Kawaguchi, Y., Katsumata, Y. et al. Clinical manifestations of neurological involvement in primary Sjögren’s syndrome. Clin Rheumatol 30, 485–490 (2011). https://doi.org/10.1007/s10067-010-1458-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-010-1458-7