Abstract
An increase in reports of systemic lupus erythematosus (SLE) related to tumour necrosis factor inhibitor (TNFi) therapy has recently been highlighted. We report new-onset SLE in a 22-year-old woman after 13 months of infliximab for ankylosing spondylitis (AS). Lupus symptoms promptly resolved and serologic abnormalities improved after infliximab was ceased. A flare of AS symptoms after 2 months prompted cautious introduction of an alternative TNFi, etanercept. At 14 months follow-up, neither clinical nor serologic flare of lupus had occurred. To our knowledge, this is the third reported case of infliximab-related lupus that did not recur on switching to an alternative TNFi.
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Disclosures
Dr. Lionel Schachna has obtained speaker fees for presentations to rheumatologists and general practitioners on ankylosing spondylitis. The Austin Spondylitis Clinic obtains funds from the three TNF inhibitor pharmaceutical companies. Dr. Schachna has also obtained travel assistance to attend the American College of Rheumatology ASM from Abbott.
Dr. Russell Buchanan has given talks to hospital residents and general practitioners in sessions funded by Wyeth and Abbott. He attended three meetings over the last 2 years of the Australian Humira Medical Advisory Board following which Abbott provided funding for attendance to the 2009 Australian Rheumatology Association and 2008 European League Against Rheumatism (EULAR) annual scientific meetings. Wyeth provided funds for an unrestricted education grant for research activities within the Department of Rheumatology, Austin Health.
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Luong, J.M.T., Tan, B.T., Buchanan, R.R.C. et al. Tumour necrosis factor inhibitor-related lupus: safety of switching agents. Clin Rheumatol 29, 551–553 (2010). https://doi.org/10.1007/s10067-009-1365-y
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DOI: https://doi.org/10.1007/s10067-009-1365-y