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Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients

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Abstract

The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1) levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher prevalence of hypertension (63.6% vs. 21.6%, p = 0.001) and higher levels of triglycerides (129.5 mg/dL ± 70.8 vs. 88.4 mg/dL ± 60.8, p = 0.017) than controls. Mean number of CVD risk factors was 1.64 ± 1.22 in TA patients and 1.03 ± 1.44 among controls, p = 0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p = 0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL ± 0.45 vs. 1.27 pg/mL ± 0.32, p = 0.034), however no significant difference was found between patients with active and inactive disease. In this study, TA patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls.

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Acknowledgments

The authors thank Themis Mizerkovisk Torres and Maria Teresa Costa for their valuable contribution for the development of this study.

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Authors and Affiliations

  1. Rheumatology Division, Universidade Federal de São Paulo—UNIFESP, Rua Botucatu, 740, 04023-900, São Paulo, SP, Brazil

    Alexandre Wagner Silva de Souza, Henrique Ataíde Mariz, Edgard Torres Reis Neto, Anne Elizabeth Diniz Arraes, Neusa Pereira da Silva & Emília Inoue Sato

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  1. Alexandre Wagner Silva de Souza
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  2. Henrique Ataíde Mariz
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  3. Edgard Torres Reis Neto
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  4. Anne Elizabeth Diniz Arraes
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  6. Emília Inoue Sato
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Correspondence to Alexandre Wagner Silva de Souza.

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de Souza, A.W.S., Ataíde Mariz, H., Torres Reis Neto, E. et al. Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients. Clin Rheumatol 28, 379–383 (2009). https://doi.org/10.1007/s10067-008-1056-0

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  • DOI: https://doi.org/10.1007/s10067-008-1056-0

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