Skip to main content

Advertisement

Log in

Diagnosis delay in patients with ankylosing spondylitis: factors and outcomes—an Indian perspective

  • Brief Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

This study focuses on the causes and consequences of delay in diagnosis of ankylosing spondylitis (AS). Seventy consecutive patients presenting at a rheumatology clinic in India were studied. Mean (±S.D) delay in diagnosis was 6.9 (±5.2) years. The main cause of delay was incorrect diagnosis as non-specific back pain (19/54, 35.1%), degenerative disc disease (14/54, 25.9%), rheumatoid arthritis (11/54, 20.37%), and tuberculosis of spine (9/54, 16.6%) in that order, for which the patient received prolonged treatment. Absence of extra-articular manifestations and juvenile age also significantly correlated with diagnostic delay. Delay in diagnosis resulted in significantly worse disease activity index (BASDAI), functional index (BASFI), and damage index (BASMI). Most incorrect initial diagnoses were made by orthopedicians (75.9%), followed by general physician (50%), and rheumatologist (12%). Continuing medical education workshops with a focus on clinical diagnosis of inflammatory back pain may help in early diagnosis of AS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Khan MA (2002) Ankylosing spondylitis: introductory comments on its diagnosis and treatment. Ann Rheum Dis 61(Suppl 3):iii3–iii7

    PubMed  Google Scholar 

  2. Dincer U, Cakar E, Kiralp MZ, Dursun H (2008) Diagnosis delay in patients with ankylosing spondylitis: possible reasons and proposals for new diagnostic criteria. Clin Rheumatol 27(4):457–462

    Article  PubMed  Google Scholar 

  3. Feldtkeller E, Erlendsson J (2008) Definition of disease duration in ankylosing spondylitis. Rheumatol Int 28(7):693–696

    Article  PubMed  Google Scholar 

  4. Feldtkeller E, Khan MA, van der Heijde D, van der Linden S, Braun J (2003) Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 23(2):61–66

    PubMed  Google Scholar 

  5. Van Den Bosch F, Kruithof E, Baeten D, Herssens A, de Keyser F, Mielants H et al (2002) Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (infliximab) versus placebo in active spondylarthropathy. Arthritis Rheum 46(3):755–765

    Article  Google Scholar 

  6. Gorman JD, Sack KE, Davis JC Jr (2002) Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha. N Engl J Med 346(18):1349–1356

    Article  PubMed  CAS  Google Scholar 

  7. Brandt J, Khariouzov A, Listing J, Haibel H, Sorensen H, Grassnickel L et al (2003) Six-month results of a double-blind, placebo-controlled trial of etanercept treatment in patients with active ankylosing spondylitis. Arthritis Rheum 48(6):1667–1675

    Article  PubMed  CAS  Google Scholar 

  8. Rudwaleit M, Listing J, Brandt J, Braun J, Sieper J (2004) Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis. Ann Rheum Dis 63(6):665–670

    Article  PubMed  CAS  Google Scholar 

  9. Deyo RA, Weinstein JN (2001) Low back pain. N Engl J Med 344(5):363–370

    Article  PubMed  CAS  Google Scholar 

  10. Moll JM, Wright V (1973) New York clinical criteria for ankylosing spondylitis. A statistical evaluation. Ann Rheum Dis 32(4):354–363

    Article  PubMed  CAS  Google Scholar 

  11. Oostveen J, Prevo R, den Boer J, van de Laar M (1999) Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study. J Rheumatol 26(9):1953–1958

    PubMed  CAS  Google Scholar 

  12. Braun J, Baraliakos X, Golder W, Brandt J, Rudwaleit M, Listing J et al (2003) Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis, before and after successful therapy with infliximab: evaluation of a new scoring system. Arthritis Rheum 48(4):1126–1136

    Article  PubMed  CAS  Google Scholar 

  13. van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27(4):361–368

    Article  PubMed  Google Scholar 

  14. van der Heijde D, van der Linden S, Bellamy N, Calin A, Dougados M, Khan MA (1999) Which domains should be included in a core set for endpoints in ankylosing spondylitis? Introduction to the ankylosing spondylitis module of OMERACT IV. J Rheumatol 26(4):945–947

    PubMed  Google Scholar 

  15. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12):2286–2291

    PubMed  CAS  Google Scholar 

  16. Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P et al (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 21(12):2281–2285

    PubMed  CAS  Google Scholar 

  17. Jones SD, Porter J, Garrett SL, Kennedy LG, Whitelock H, Calin A (1995) A new scoring system for the Bath Ankylosing Spondylitis Metrology Index (BASMI). J Rheumatol 22(8):1609

    PubMed  CAS  Google Scholar 

  18. Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W et al (2002) Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 359(9313):1187–1193

    Article  PubMed  CAS  Google Scholar 

  19. Baraliakos X, Listing J, von der Recke A et al (2008) The long-term natural course of radiographic progression in ankylosing spondylitis—evaluation of a large AS cohort Scand J Rheumatol 37(123s):33. [Abstract from the 32nd Scandinavian Congress of Rheumatology Jan 30–Feb 3, 2008, held at Levi, Lapland, Finland]

  20. Calin A, Elswood J, Rigg S, Skevington SM (1988) Ankylosing spondylitis—an analytical review of 1500 patients: the changing pattern of disease. J Rheumatol 15(8):1234–1238

    PubMed  CAS  Google Scholar 

  21. Malaviya AN (2003) The Feng Pao Hsii lecture: rheumatology in the Asia-Pacific region—unmet needs and challenges. APLAR J Rheumatol 6(1):68–76

    Article  Google Scholar 

  22. Rudwaleit M, Metter A, Listing J, Sieper J, Braun J (2006) Inflammatory back pain in ankylosing spondylitis: a reassessment of the clinical history for application as classification and diagnostic criteria. Arthritis Rheum 54(2):569–578

    Article  PubMed  Google Scholar 

Download references

Disclosures

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anand N. Malaviya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aggarwal, R., Malaviya, A.N. Diagnosis delay in patients with ankylosing spondylitis: factors and outcomes—an Indian perspective. Clin Rheumatol 28, 327–331 (2009). https://doi.org/10.1007/s10067-008-1049-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-008-1049-z

Keywords

Navigation