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The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis

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Abstract

The objective of this study was to investigate the frequency of sacroiliitis in familial Mediterranean fever (FMF) patients and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. The study group consisted of 256 FMF patients (male 128, female 128, mean age 27.2 ± 6.3 years). After evaluation of the medical records, 70 patients (27.4%) were determined to have one or more of musculoskeletal manifestations. Sacroiliitis was determined in 18 (32.7%) FMF patients. The frequency of sacroiliitis among all FMF patients was found to be 7%. HLA-B27 was 47% and 6.3% in FMF patients with and without sacroiliitis, respectively. The frequency of M694V mutations in FMF patients with sacroiliitis was 93.7%. Sacroiliitis may be seen more frequently in FMF patients than expected. HLA-B27 positivity and/or M694V mutation may play a role in the development of sacroiliitis and the severity of seronegative spondyloarthropathy.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey

    Timuçin Kaşifoğlu, Cüneyt Çalışır, Döndü Ü. Cansu & Cengiz Korkmaz

  2. Department of Radiology, Eskişehir Osmangazi University, Eskişehir, Turkey

    Cüneyt Çalışır

  3. Vişnelik Mah. Alifuat Güven Cad, Akasya Sok. 11/11, Eskişehir, 26020, Turkey

    Cengiz Korkmaz

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  1. Timuçin Kaşifoğlu
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  2. Cüneyt Çalışır
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  3. Döndü Ü. Cansu
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  4. Cengiz Korkmaz
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Correspondence to Cengiz Korkmaz.

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Kaşifoğlu, T., Çalışır, C., Cansu, D.Ü. et al. The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. Clin Rheumatol 28, 41–46 (2009). https://doi.org/10.1007/s10067-008-0980-3

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  • DOI: https://doi.org/10.1007/s10067-008-0980-3

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