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Change in serum uric acid between baseline and 1-year follow-up and its associated factors in male subjects

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Abstract

A number of cross-sectional analysis studies have been conducted to determine the relationships between serum uric acid and related variables or clinical manifestations. However, few data related to changes in serum uric acid within the same cohort population at two separate periods of time have been reported. In this study, we investigated the changes in serum uric acid in a population from baseline to 1-year follow-up and examined the associations with related parameters and medical conditions. A total of 1,437 eligible male subjects who underwent 2 medical examinations at a health promotion center at an interval of approximately 12 months were enrolled in this study. Data were obtained from routine physical assessments such as blood pressure, height, waist circumference, blood analyses for liver function, renal function, lipid profile, and electrolytes, along with standardized questionnaires including self-reported data. In this population, serum uric acid was significantly increased at 1-year follow-up compared with the baseline level (5.94 ± 1.20 vs 5.99 ± 1.22, p = 0.003). Changes of some confounders such as total bilirubin, creatinine, BUN, phosphorus, total cholesterol, and triglyceride were significantly associated with changes in serum uric acid. Among them, serum creatinine may be the most influential in determining the serum uric acid level (odds ratio = 21.691, 95%CI = 5.110–92.086). A change of serum uric acid over 1 year did not seem to affect changes in the clinical status for some medical conditions including hypertension, diabetes mellitus, cardiovascular disease, and metabolic syndrome. This analysis showed that a change in serum creatinine level between baseline and 1-year follow-up might be the most potent factor affecting a change in serum uric acid in healthy, male subjects. Changes of serum uric acid did not show any meaningful impact on the development of hypertension, heart failure, diabetes mellitus, and metabolic syndrome in this 1-year follow-up study.

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References

  1. Ghei M, Mihailescu M, Levinson D (2002) Pathogenesis of hyperuricemia: recent advances. Curr Rheumatol Rep 4:270–274

    Article  PubMed  Google Scholar 

  2. Sica DA, Schoolwerth AC (2002) Part 1. Uric acid and losartan. Curr Opin Nephrol Hypertens 11:475–482

    Article  PubMed  Google Scholar 

  3. Enomoto A, Kimura H, Chairoungdua A et al (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447–452

    PubMed  CAS  Google Scholar 

  4. Shima Y, Teruya K, Ohta H (2006) Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese. Life Sci 79:2234–2237

    Article  PubMed  CAS  Google Scholar 

  5. Nan H, Qiao Q, Dong Y et al (2006) The prevalence of hyperuricemia in a population of the coastal city of Qingdao, China. J Rheumatol 33:1346–1350

    PubMed  Google Scholar 

  6. Lohsoonthorn V, Dhanamun B, Williams MA (2006) Prevalence of hyperuricemia and its relationship with metabolic syndrome in Thai adults receiving annual health exams. Arch Med Res 37:883–889

    Article  PubMed  CAS  Google Scholar 

  7. Kim EH, Jeon K, Park KW et al (2004) The prevalence of gout among hyperuricemic population. J Korean Rheum Assoc 11:7–13

    Google Scholar 

  8. Rott KT, Agudelo CA (2003) Gout. JAMA 289:2857–2860

    Article  PubMed  Google Scholar 

  9. Rho YH, Choi SJ, Lee YH et al (2005) The prevalence of metabolic syndrome in patients with gout: a multicenter study. J Korean Med Sci 20:1029–1033

    Article  PubMed  CAS  Google Scholar 

  10. Mellen PB, Bleyer AJ, Erlinger TP et al (2006) Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study. Hypertension 48:1037–1042

    Article  PubMed  CAS  Google Scholar 

  11. Conen D, Wietlisbach V, Bovet P et al (2004) Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health 4:9

    Article  PubMed  CAS  Google Scholar 

  12. Lin KC, Tsao HM, Chen CH et al (2004) Hypertension was the major risk factor leading to development of cardiovascular diseases among men with hyperuricemia. J Rheumatol 31:1152–1158

    PubMed  Google Scholar 

  13. Culleton BF, Larson MG, Kannel WB et al (1999) Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 131:7–13

    PubMed  CAS  Google Scholar 

  14. Nakanishi N, Suzuki K, Kawashimo H et al (1999) Serum uric acid: correlation with biological, clinical and behavioral factors in Japanese men. J Epidemiol 9:99–106

    PubMed  CAS  Google Scholar 

  15. Munan L, Kelly A, Petitclerc C (1976) Population serum urate levels and their correlates. The Sherbrooke regional study. Am J Epidemiol 103:369–382

    PubMed  CAS  Google Scholar 

  16. Fang J, Alderman MH (2000) Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA 283:2404–2410

    Article  PubMed  CAS  Google Scholar 

  17. Anonymous (1999) 1999 World Health Organization–International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines Subcommittee. J Hypertens 17:151–183

    Google Scholar 

  18. Anonymous (1997) Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183–1197

    Google Scholar 

  19. Eckel RH, Grundy SM, Zimmet PZ (2005) The metabolic syndrome. Lancet 365:1415–1428

    Article  PubMed  CAS  Google Scholar 

  20. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486–2497

    Google Scholar 

  21. World Health Organisation Western Pacific Region (2000) The Asia-Pacific perspective: redefining obesity and its treatment. Co-sponsored by the Regional Office for the Western Pacific, World Health Organization, International Association for the Study of Obesity and the International Obesity Task Force

  22. Baillie JK, Bates MG, Thompson AA et al (2007) Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Chest 131:1473–1478

    Article  PubMed  CAS  Google Scholar 

  23. Lin JD, Chiou WK, Chang HY et al (2007) Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid. Metabolism 56:751–756

    Article  PubMed  CAS  Google Scholar 

  24. Rathmann W, Haastert B, Icks A et al (2007) Ten-year change in serum uric acid and its relation to changes in other metabolic risk factors in young black and white adults: the CARDIA study. Eur J Epidemiol 22(7):439–445. DOI 10.1007/s10654-007-9132-3

    Article  PubMed  CAS  Google Scholar 

  25. Perez-Ruiz F, Calabozo M, Herrero-Beites AM et al (2000) Improvement of renal function in patients with chronic gout after proper control of hyperuricemia and gouty bouts. Nephron 86:287–291

    Article  PubMed  CAS  Google Scholar 

  26. Darmawan J, Rasker JJ, Nuralim H (2003) The effect of control and self-medication of chronic gout in a developing country. Outcome after 10 years. J Rheumatol 30:2437–2443

    PubMed  Google Scholar 

  27. Bairaktari E, Liamis G, Tsolas O et al (2001) Partially reversible renal tubular damage in patients with obstructive jaundice. Hepatology 33:1365–1369

    Article  PubMed  CAS  Google Scholar 

  28. Mielants H, Veys EM, de Weerdt A (1973) Gout and its relation to lipid metabolism. II. Correlations between uric acid, lipid, and lipoprotein levels in gout. Ann Rheum Dis 32:506–509

    Article  PubMed  CAS  Google Scholar 

  29. Shankar A, Klein R, Klein BE et al (2006) The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study. J Hum Hypertens 20:937–945

    Article  PubMed  CAS  Google Scholar 

  30. Perlstein TS, Gumieniak O, Williams GH et al (2006) Uric acid and the development of hypertension: the normative aging study. Hypertension 48:1031–1036

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-Dong, Namgu, Daegu, 705-718, South Korea

    Jung-Yoon Choe, Sung-Hoon Park, Ji-Young Kim & Seong-Kyu Kim

  2. Department of Medical Statistics, Catholic University of Daegu School of Medicine, Daegu, South Korea

    Im-Hee Shin

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  1. Jung-Yoon Choe
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  2. Sung-Hoon Park
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  3. Ji-Young Kim
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  4. Im-Hee Shin
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  5. Seong-Kyu Kim
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Correspondence to Seong-Kyu Kim.

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Choe, JY., Park, SH., Kim, JY. et al. Change in serum uric acid between baseline and 1-year follow-up and its associated factors in male subjects. Clin Rheumatol 27, 483–489 (2008). https://doi.org/10.1007/s10067-007-0732-9

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  • DOI: https://doi.org/10.1007/s10067-007-0732-9

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