Skip to main content

Advertisement

SpringerLink
Log in

Clinical features of scleroderma patients with contracture of phalanges

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Contracture of phalanges (CP) is a frequent complication of patients with systemic sclerosis (SSc). The objective of this study was to examine the prevalance of CP in patients with SSc and investigate the clinical and laboratory features of SSc patients with CP. Three hundred and fifty patients with SSc were examined. CP was found in 164 of the 350 patients (47%) with SSc. The prevalence of oesophageal involvement, pulmonary fibrosis or heart involvement was significantly greater in the patients with CP than that in those without CP. Our study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Shero JH, Bordwell B, Rothfield NF, Earnshaw WC (1986) High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients. Science 231:737–740

    Article  PubMed  CAS  Google Scholar 

  2. Ihn H, Yamane K, Yazawa N et al (1999) Distribution and antigen specificity of anti-U1 RNP antibodies in patients with systemic sclerosis. Clin Exp Immunol 117:383–387

    Article  PubMed  CAS  Google Scholar 

  3. Clark JA, Winkelmann R, McDuffie FC, Ward LE (1971) Synovial tissue changes and rheumatoid factor in scleroderma. Mayo Clin Proc 46:97–103

    PubMed  CAS  Google Scholar 

  4. Sato S, Ihn H, Kikuchi K, Takehara K (1994) Antihistone antibobodies in systemic sclerosis. Association with pulmonary fibrosis. Arthritis Rheum 37:391–394

    Article  PubMed  CAS  Google Scholar 

  5. Serup J, Staun-Olsen P (1986) Antinuclear antibodies and anti-DNA antibodies in scleroderma. Allergy 41:452–456

    Article  PubMed  CAS  Google Scholar 

  6. Yamane K, Ihn H, Asano Y, Yazawa N, Kubo M, Kikuchi K, Soma Y, Tamaki K (2000) Clinical and laboratory features of scleroderma patients with pulmonary hypertension. Rheumatology 39:1269–1271

    Article  PubMed  CAS  Google Scholar 

  7. Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (2005) Clinical and laboratory features of scleroderma patients developing skeletal myopathy. Clin Rheumatol 24:99–102

    Article  PubMed  Google Scholar 

  8. Tamaki T, Mori S, Takehara K (1991) Epidemiological study of patients with systemic sclerosis in Tokyo. Arch Dermatol Res 283:366–371

    Article  PubMed  CAS  Google Scholar 

  9. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, Rowell N, Wollheim F (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15:202–205

    PubMed  CAS  Google Scholar 

  10. Steen VD, Powell DL, Medsger TA Jr (1988) Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum 31:196–203

    Article  PubMed  CAS  Google Scholar 

  11. Ihn H, Sato S, Fujimoto M, Kikuchi K, Igarashi A, Soma Y, Tamaki K, Takehara K (1996) Measurement of anticardiolipin antibodies by ELISA using beta 2-glycoprotein I (beta 2-GPI) in systemic sclerosis. Clin Exp Immunol 105:475–479

    Article  PubMed  CAS  Google Scholar 

  12. Yune HY, Vix VA, Klatte EC (1971) Early fingertip changes in scleroderma. JAMA 215:1113–1116

    Article  PubMed  CAS  Google Scholar 

  13. Wild W, Beetham WP (1975) Erosive arthropathy in systemic scleroderma. JAMA 232:511–512

    Article  PubMed  CAS  Google Scholar 

  14. Steen VD, Ziegler GL, Rodnan GP et al (1984) Clinical and laboratory association of anticentromere antibody in patients with progressive systemic sclerosis. Arthritis Rheum 27:125–131

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Ryuichi Ashida, Hironobu Ihn, Yoshihiro Mimura, Masatoshi Jinnin, Yoshihide Asano, Masahide Kubo & Kunihiko Tamaki

  2. Department of Dermatology, Mita Hospital, Internationl University of Health and Welfare, Tokyo, Japan

    Ryuichi Ashida & Masahide Kubo

  3. Department of Dermatology & Plastic and Reconstructive Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Hironobu Ihn

Authors
  1. Ryuichi Ashida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hironobu Ihn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshihiro Mimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masatoshi Jinnin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshihide Asano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahide Kubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kunihiko Tamaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hironobu Ihn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ashida, R., Ihn, H., Mimura, Y. et al. Clinical features of scleroderma patients with contracture of phalanges. Clin Rheumatol 26, 1275–1277 (2007). https://doi.org/10.1007/s10067-006-0490-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-006-0490-0

Keywords

Search

Navigation